Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies
The human 80S ribosome is the cellular nucleoprotein nanomachine in charge of protein synthesis that is profoundly affected during cancer transformation by oncogenic proteins and provides cancerous proliferating cells with proteins and therefore biomass. Indeed, cancer is associated with an increase...
Main Authors: | Arnaud Gilles, Léo Frechin, Kundhavai Natchiar, Giulia Biondani, Ottilie von Loeffelholz, Samuel Holvec, Julie-Lisa Malaval, Jean-Yves Winum, Bruno P. Klaholz, Jean-François Peyron |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/3/629 |
Similar Items
-
Metformin, an Anti-diabetic Drug to Target Leukemia
by: Giulia Biondani, et al.
Published: (2018-08-01) -
The ribosomal database project /
by: Larsen, Niels -
Protein synthesis and ribosome structure : translating the genome /
by: Nierhaus, Knud H., et al.
Published: (2004) -
Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins
by: Annalisa Pecoraro, et al.
Published: (2021-05-01) -
Specialized Ribosomes in Health and Disease
by: Sarah C. Miller, et al.
Published: (2023-03-01)