Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
Summary: Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion ability that is further increased by obesity, we ide...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472300877X |
| _version_ | 1797731082188095488 |
|---|---|
| author | Alexia Blandin Jérémy Amosse Josy Froger Grégory Hilairet Maëva Durcin Lionel Fizanne Valentine Ghesquière Xavier Prieur Julien Chaigneau Luisa Vergori Cédric Dray Jean-Philippe Pradère Stéphanie Blandin Joëlle Dupont Pierre-Henri Ducluzeau Séverine Dubois Jérôme Boursier Bertrand Cariou Soazig Le Lay |
| author_facet | Alexia Blandin Jérémy Amosse Josy Froger Grégory Hilairet Maëva Durcin Lionel Fizanne Valentine Ghesquière Xavier Prieur Julien Chaigneau Luisa Vergori Cédric Dray Jean-Philippe Pradère Stéphanie Blandin Joëlle Dupont Pierre-Henri Ducluzeau Séverine Dubois Jérôme Boursier Bertrand Cariou Soazig Le Lay |
| author_sort | Alexia Blandin |
| collection | DOAJ |
| description | Summary: Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion ability that is further increased by obesity, we identify enrichment of oligomeric forms of adiponectin in small EVs (sEVs). This adipokine is mainly distributed at the EV external surface as a result of nonspecific adsorption of soluble adiponectin. EVs also constitute stable conveyors of adiponectin in the blood circulation. Adiponectin-enriched sEVs display in vitro insulin-sensitizing effects by binding to regular adiponectin receptors. Adoptive transfer of adiponectin-enriched sEVs in high-fat-diet-fed mice prevents animals from gaining weight and ameliorated insulin resistance and tissue inflammation, with major effects observed in the AT and liver. Our results therefore provide information regarding adiponectin-related metabolic responses by highlighting EVs as delivery platforms of metabolically active forms of adiponectin molecules. |
| first_indexed | 2024-03-12T11:53:25Z |
| format | Article |
| id | doaj.art-51a5b96eeb9b44f8afe7503fe5c1d883 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-12T11:53:25Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-51a5b96eeb9b44f8afe7503fe5c1d8832023-08-31T05:01:57ZengElsevierCell Reports2211-12472023-08-01428112866Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory propertiesAlexia Blandin0Jérémy Amosse1Josy Froger2Grégory Hilairet3Maëva Durcin4Lionel Fizanne5Valentine Ghesquière6Xavier Prieur7Julien Chaigneau8Luisa Vergori9Cédric Dray10Jean-Philippe Pradère11Stéphanie Blandin12Joëlle Dupont13Pierre-Henri Ducluzeau14Séverine Dubois15Jérôme Boursier16Bertrand Cariou17Soazig Le Lay18L’Institut du Thorax, CNRS, INSERM, Nantes Université, 44000 Nantes, France; Université Angers, SFR ICAT, 49000 Angers, FranceUniversité Angers, SFR ICAT, 49000 Angers, France; IRSET Laboratory, Inserm, UMR 1085, Rennes, FranceL’Institut du Thorax, CNRS, INSERM, Nantes Université, 44000 Nantes, France; Université Angers, SFR ICAT, 49000 Angers, FranceUniversité Angers, SFR ICAT, 49000 Angers, FranceUniversité Angers, SFR ICAT, 49000 Angers, FranceHIFIH, CHU Angers, Université Angers, SFR ICAT, 49000 Angers, FranceL’Institut du Thorax, CNRS, INSERM, Nantes Université, 44000 Nantes, France; Université Angers, SFR ICAT, 49000 Angers, FranceL’Institut du Thorax, CNRS, INSERM, Nantes Université, 44000 Nantes, FranceHIFIH, CHU Angers, Université Angers, SFR ICAT, 49000 Angers, FranceUniversité Angers, SFR ICAT, 49000 Angers, FranceRESTORE, UMR 1301 Inserm, 5070 CNRS, Université Paul Sabatier, Toulouse, FranceRESTORE, UMR 1301 Inserm, 5070 CNRS, Université Paul Sabatier, Toulouse, FranceCHU Nantes, CNRS, Inserm BioCore US16, SFR Bonamy, Nantes Université, 44000 Nantes, FranceCNRS, IFCE, INRAE, PRC, Université de Tours, 37380 Nouzilly, FranceCNRS, IFCE, INRAE, PRC, Université de Tours, 37380 Nouzilly, France; Service de Médecine Interne, Unité d'Endocrinologie Diabétologie et Nutrition, Centre Hospitalier Universitaire et Faculté de Médecine, Université de Tours, Tours, FranceCHU Angers, Angers, FranceHIFIH, CHU Angers, Université Angers, SFR ICAT, 49000 Angers, France; CHU Angers, Angers, FranceL’Institut du Thorax, CNRS, INSERM, Nantes Université, 44000 Nantes, FranceL’Institut du Thorax, CNRS, INSERM, Nantes Université, 44000 Nantes, France; Université Angers, SFR ICAT, 49000 Angers, France; CorrespondenceSummary: Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion ability that is further increased by obesity, we identify enrichment of oligomeric forms of adiponectin in small EVs (sEVs). This adipokine is mainly distributed at the EV external surface as a result of nonspecific adsorption of soluble adiponectin. EVs also constitute stable conveyors of adiponectin in the blood circulation. Adiponectin-enriched sEVs display in vitro insulin-sensitizing effects by binding to regular adiponectin receptors. Adoptive transfer of adiponectin-enriched sEVs in high-fat-diet-fed mice prevents animals from gaining weight and ameliorated insulin resistance and tissue inflammation, with major effects observed in the AT and liver. Our results therefore provide information regarding adiponectin-related metabolic responses by highlighting EVs as delivery platforms of metabolically active forms of adiponectin molecules.http://www.sciencedirect.com/science/article/pii/S221112472300877XCP: Metabolism |
| spellingShingle | Alexia Blandin Jérémy Amosse Josy Froger Grégory Hilairet Maëva Durcin Lionel Fizanne Valentine Ghesquière Xavier Prieur Julien Chaigneau Luisa Vergori Cédric Dray Jean-Philippe Pradère Stéphanie Blandin Joëlle Dupont Pierre-Henri Ducluzeau Séverine Dubois Jérôme Boursier Bertrand Cariou Soazig Le Lay Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties Cell Reports CP: Metabolism |
| title | Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties |
| title_full | Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties |
| title_fullStr | Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties |
| title_full_unstemmed | Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties |
| title_short | Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties |
| title_sort | extracellular vesicles are carriers of adiponectin with insulin sensitizing and anti inflammatory properties |
| topic | CP: Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S221112472300877X |
| work_keys_str_mv | AT alexiablandin extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT jeremyamosse extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT josyfroger extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT gregoryhilairet extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT maevadurcin extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT lionelfizanne extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT valentineghesquiere extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT xavierprieur extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT julienchaigneau extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT luisavergori extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT cedricdray extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT jeanphilippepradere extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT stephanieblandin extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT joelledupont extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT pierrehenriducluzeau extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT severinedubois extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT jeromeboursier extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT bertrandcariou extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties AT soaziglelay extracellularvesiclesarecarriersofadiponectinwithinsulinsensitizingandantiinflammatoryproperties |