IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model

IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model

Mesenchymal stem cells (MSCs) are used in various studies to induce immunomodulatory effects in clinical conditions associated with immune dysregulation such as graft versus host disease (GvHD). However, most of these clinical trials failed to go beyond early phase 2 studies because of limited effic...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Cuiping Zhang, Mina Delawary, Peng Huang, Jennifer A. Korchak, Koji Suda, Abba C. Zubair
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	MDPI AG 2021-11-01
Σειρά:	Cells
Θέματα:	mRNA engineered MSCs interleukin 10 immunosuppression graft versus host disease
Διαθέσιμο Online:	https://www.mdpi.com/2073-4409/10/11/3101

Παρόμοια τεκμήρια

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis
ανά: Shai eYarkoni, κ.ά.
Έκδοση: (2014-05-01)

Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD
ανά: Jongbok Lee, κ.ά.
Έκδοση: (2025-01-01)

Spontaneous xenogeneic GvHD in Wilms' tumor Patient‐Derived xenograft models and potential solutions
ανά: Seyed Mostafa Monzavi, κ.ά.
Έκδοση: (2022-08-01)

Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans Syndrome
ανά: Robin Reschke, κ.ά.
Έκδοση: (2022-08-01)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
ανά: Jaeyoon Ryu, κ.ά.
Έκδοση: (2020-06-01)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
ανά: Sybille Landwehr-Kenzel, κ.ά.
Έκδοση: (2021-10-01)

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation
ανά: Mauro Di Ianni, κ.ά.
Έκδοση: (2024-01-01)

The Role of Bacteria and Pattern Recognition Receptors in GvHD
ανά: E. Holler, κ.ά.
Έκδοση: (2010-01-01)

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD
ανά: Weijia Zhao, κ.ά.
Έκδοση: (2023-08-01)

Impact of Resistance Exercise and Nutritional Endorsement on physical performance in patients with GvHD (IRENE-G study) – design and rational of a randomized controlled trial
ανά: Janina Bujan Rivera, κ.ά.
Έκδοση: (2022-04-01)

Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide
ανά: Raffaella Greco, κ.ά.
Έκδοση: (2019-10-01)

Decreased Plasma Level of Cytokeratin 20 (KRT20) Is Indicative of the Emergence and Severity of Acute GvHD Irrespective to the Type of Organ Involvement
ανά: Nikolett Lupsa, κ.ά.
Έκδοση: (2022-02-01)

Cushing Syndrome: The Role of MSCs in Wound Healing, Immunosuppression, Comorbidities, and Antioxidant Imbalance
ανά: Miriam Caffarini, κ.ά.
Έκδοση: (2019-10-01)

Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease
ανά: Qinjun Zhao, κ.ά.
Έκδοση: (2019-11-01)

TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment
ανά: Zhenghou Zhang, κ.ά.
Έκδοση: (2022-07-01)

Modulation of T-regulatory cells by small molecules: potential therapy for GvHD
ανά: Leuschner, U
Έκδοση: (2021)

Immunometabolic Therapeutic Targets of Graft-versus-Host Disease (GvHD)
ανά: Kudakwashe Mhandire, κ.ά.
Έκδοση: (2021-10-01)

Effect of the YCD3-1 Anti-Mouse Monoclonal on Murine GvHD
ανά: James P. Okunewick, κ.ά.
Έκδοση: (1993-07-01)

Bone marrow GvHD after allogeneic hematopoietic stem cell transplantation
ανά: Martin eSzyska, κ.ά.
Έκδοση: (2016-03-01)

CD317+ MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities
ανά: Jun Song, κ.ά.
Έκδοση: (2024-01-01)

Extracorporeal photopheresis as an immunomodulatory treatment modality for chronic GvHD and the importance of emerging biomarkers
ανά: Ines Bojanic, κ.ά.
Έκδοση: (2023-02-01)

Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival
ανά: Lambros Kordelas, κ.ά.
Έκδοση: (2021-09-01)

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
ανά: Lucas-Sebastian Spitzhorn, κ.ά.
Έκδοση: (2019-03-01)

A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD
ανά: Peilong Lai, κ.ά.
Έκδοση: (2018-12-01)

Current Approaches for the Prevention and Treatment of Acute and Chronic GVHD
ανά: Attilio Olivieri, κ.ά.
Έκδοση: (2024-09-01)

In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.
ανά: Kottaridis, P, κ.ά.
Έκδοση: (2001)

HSCT with Mismatched Unrelated Donors (MMUD): A Comparison of Different Platforms for GvHD Prophylaxis
ανά: Massimo Berger, κ.ά.
Έκδοση: (2022-02-01)

Correction to: Tregs and GvHD prevention by extracorporeal photopheresis: observations from a clinical trial
ανά: Roberto Crocchiolo, κ.ά.
Έκδοση: (2021-03-01)

The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD following Hematopoietic Stem Cell Transplantation
ανά: Seyed Asadollah Mousavi, κ.ά.
Έκδοση: (2016-12-01)

Accumulation of T-cell-suppressive PD-L1high extracellular vesicles is associated with GvHD and might impact GvL efficacy
ανά: Regina Jitschin, κ.ά.
Έκδοση: (2023-03-01)

In silico analysis of RNA and small RNA sequencing data from human BM-MSCs and differentiated osteocytes, chondrocytes and tenocytes
ανά: Srinivas V. Koduru, κ.ά.
Έκδοση: (2021-01-01)

Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities
ανά: Swati Paliwal, κ.ά.
Έκδοση: (2018-11-01)

Campath 1 H "in the bag" is an effective method of GvHD prevention in allogeneic stem cell transplantation.
ανά: Potter, M, κ.ά.
Έκδοση: (2000)

Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
ανά: Haroon Shaikh, κ.ά.
Έκδοση: (2022-11-01)

The role of animal models in the study of hematopoietic stem cell transplantation and GvHD: A historical overview.
ανά: Margherita Boieri, κ.ά.
Έκδοση: (2016-08-01)

Posttransplant de novo DSA and NDSA affect GvHD, OS, and DFS after haplo-HSCT in patients without pre-existing HLA antibodies of hematological malignancies
ανά: Lan Wang, κ.ά.
Έκδοση: (2022-12-01)

Separation of GVL from GVHD -location, location, location
ανά: Takanori Teshima, κ.ά.
Έκδοση: (2023-12-01)

Regulatory T Cells in GVHD Therapy
ανά: Wen-wen Guo, κ.ά.
Έκδοση: (2021-06-01)

Quality of life of patients with graft-versus-host disease (GvHD) post-hematopoietic stem cell transplantation
ανά: Sibéli de Fátima Ferraz Simão Proença, κ.ά.

GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics
ανά: Sakhila Ghimire, κ.ά.
Έκδοση: (2021-10-01)