Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease
The association between shifts in gut microbiome composition and metabolic disorders is a well-recognized phenomenon. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Fecal microbiome transplantation (FMT) is a method to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/220 |
| _version_ | 1797619960417091584 |
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| author | Vanessa Stadlbauer |
| author_facet | Vanessa Stadlbauer |
| author_sort | Vanessa Stadlbauer |
| collection | DOAJ |
| description | The association between shifts in gut microbiome composition and metabolic disorders is a well-recognized phenomenon. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Fecal microbiome transplantation (FMT) is a method to alter a person’s microbiome composition. Although this method allowed for the establishment of proof of concept for using microbiome modulation to treat metabolic disorders, the method is not yet ready for broad application. It is a resource-intensive method that also carries some procedural risks and whose effects are not always reproducible. This review summarizes the current knowledge on FMT to treat metabolic diseases and gives an outlook on open research questions. Further research is undoubtedly required to find applications that are less resource-intensive, such as oral encapsulated formulations, and have strong and predictable results. Furthermore, a clear commitment from all stakeholders is necessary to move forward in the direction of developing live microbial agents, next-generation probiotics, and targeted dietary interventions. |
| first_indexed | 2024-03-11T08:34:27Z |
| format | Article |
| id | doaj.art-51a8ee5379fc49df8fdcca485d22aef9 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T08:34:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-51a8ee5379fc49df8fdcca485d22aef92023-11-16T21:32:24ZengMDPI AGJournal of Personalized Medicine2075-44262023-01-0113222010.3390/jpm13020220Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic DiseaseVanessa Stadlbauer0Department of Gastroenterology and Hepatology, Medical University of Graz, 8036 Graz, AustriaThe association between shifts in gut microbiome composition and metabolic disorders is a well-recognized phenomenon. Clinical studies and experimental data suggest a causal relationship, making the gut microbiome an attractive therapeutic goal. Fecal microbiome transplantation (FMT) is a method to alter a person’s microbiome composition. Although this method allowed for the establishment of proof of concept for using microbiome modulation to treat metabolic disorders, the method is not yet ready for broad application. It is a resource-intensive method that also carries some procedural risks and whose effects are not always reproducible. This review summarizes the current knowledge on FMT to treat metabolic diseases and gives an outlook on open research questions. Further research is undoubtedly required to find applications that are less resource-intensive, such as oral encapsulated formulations, and have strong and predictable results. Furthermore, a clear commitment from all stakeholders is necessary to move forward in the direction of developing live microbial agents, next-generation probiotics, and targeted dietary interventions.https://www.mdpi.com/2075-4426/13/2/220microbiomeobesitymetabolic syndromefecal microbiota transplantation |
| spellingShingle | Vanessa Stadlbauer Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease Journal of Personalized Medicine microbiome obesity metabolic syndrome fecal microbiota transplantation |
| title | Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease |
| title_full | Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease |
| title_fullStr | Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease |
| title_full_unstemmed | Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease |
| title_short | Liver-Gut-Interaction: Role of Microbiome Transplantation in the Future Treatment of Metabolic Disease |
| title_sort | liver gut interaction role of microbiome transplantation in the future treatment of metabolic disease |
| topic | microbiome obesity metabolic syndrome fecal microbiota transplantation |
| url | https://www.mdpi.com/2075-4426/13/2/220 |
| work_keys_str_mv | AT vanessastadlbauer livergutinteractionroleofmicrobiometransplantationinthefuturetreatmentofmetabolicdisease |