Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series
Soft tissue tumours arise from the mesenchymal tissues of different origin like adipocytic, smooth muscles, skeletal muscle, fibroblastic/myofibroblastic, fibrohistiocytic, pericytic, vascular, osteo-cartilagineous or even unknown. Its diagnosis depends on the age of the patient and site of presenta...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/16180/53215_CE[Ra1]_F(KR)_PF1(SC_SS)_PFA(SHU)_PN(SHU).pdf |
| _version_ | 1811169157121572864 |
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| author | Vandana Maroo Sanghamitra Mukherjee Gopinath Barui Manisha Mahata |
| author_facet | Vandana Maroo Sanghamitra Mukherjee Gopinath Barui Manisha Mahata |
| author_sort | Vandana Maroo |
| collection | DOAJ |
| description | Soft tissue tumours arise from the mesenchymal tissues of different origin like adipocytic, smooth muscles, skeletal muscle, fibroblastic/myofibroblastic, fibrohistiocytic, pericytic, vascular, osteo-cartilagineous or even unknown. Its diagnosis depends on the age of the patient and site of presentation but sometimes they may present at unusual sites. Some of the tumours have overlapping histomorphological features which results in a list of differential diagnosis. Therefore, immunohistochemistry and molecular genetics play an important role for definite diagnosis. French Federation of Cancer Centres Sarcoma Group System (FNCLCC) based on necrosis, tumour grading and tumour differentiation is commonly used for grading of the sarcomas to assess the treatment response and prognosis of the patient. Hereby, authors present a series of nine cases of soft issue tumours, comprising five cases of synovial sarcomas and one each of dedifferentiated liposarcoma, rhabdomyosarcoma, epithelioid angiosarcoma and Well Differentiated Liposarcoma (WDLS). Few cases are located at unusual anatomical sites; hence, they should be kept in mind as differential diagnosis. Immunohistochemistry has played an important role for confirmation of diagnosis of synovial sarcomas and angiosarcoma. |
| first_indexed | 2024-04-10T16:38:49Z |
| format | Article |
| id | doaj.art-51a9a0553ffa4abc9b72d3c6d9d42d83 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T16:38:49Z |
| publishDate | 2022-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-51a9a0553ffa4abc9b72d3c6d9d42d832023-02-08T10:58:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-04-01164ER01ER0410.7860/JCDR/2022/53215.16180Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case SeriesVandana Maroo0Sanghamitra Mukherjee1Gopinath Barui2Manisha Mahata3Senior Resident, Department of Pathology, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India.Assistant Professor, Department of Pathology, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India.Associate Professor, Department of Pathology, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India.Assistant Professor, Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.Soft tissue tumours arise from the mesenchymal tissues of different origin like adipocytic, smooth muscles, skeletal muscle, fibroblastic/myofibroblastic, fibrohistiocytic, pericytic, vascular, osteo-cartilagineous or even unknown. Its diagnosis depends on the age of the patient and site of presentation but sometimes they may present at unusual sites. Some of the tumours have overlapping histomorphological features which results in a list of differential diagnosis. Therefore, immunohistochemistry and molecular genetics play an important role for definite diagnosis. French Federation of Cancer Centres Sarcoma Group System (FNCLCC) based on necrosis, tumour grading and tumour differentiation is commonly used for grading of the sarcomas to assess the treatment response and prognosis of the patient. Hereby, authors present a series of nine cases of soft issue tumours, comprising five cases of synovial sarcomas and one each of dedifferentiated liposarcoma, rhabdomyosarcoma, epithelioid angiosarcoma and Well Differentiated Liposarcoma (WDLS). Few cases are located at unusual anatomical sites; hence, they should be kept in mind as differential diagnosis. Immunohistochemistry has played an important role for confirmation of diagnosis of synovial sarcomas and angiosarcoma.https://www.jcdr.net/articles/PDF/16180/53215_CE[Ra1]_F(KR)_PF1(SC_SS)_PFA(SHU)_PN(SHU).pdfdedifferentiated liposarcomaepithelioid angiosarcomarhabdomyosarcomasynovial sarcomawell differentiated liposarcoma |
| spellingShingle | Vandana Maroo Sanghamitra Mukherjee Gopinath Barui Manisha Mahata Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series Journal of Clinical and Diagnostic Research dedifferentiated liposarcoma epithelioid angiosarcoma rhabdomyosarcoma synovial sarcoma well differentiated liposarcoma |
| title | Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series |
| title_full | Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series |
| title_fullStr | Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series |
| title_full_unstemmed | Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series |
| title_short | Diagnostic Challenges of Soft Tissue Sarcomas with Special Emphasis on Immunohistochemical Profile- A Case Series |
| title_sort | diagnostic challenges of soft tissue sarcomas with special emphasis on immunohistochemical profile a case series |
| topic | dedifferentiated liposarcoma epithelioid angiosarcoma rhabdomyosarcoma synovial sarcoma well differentiated liposarcoma |
| url | https://www.jcdr.net/articles/PDF/16180/53215_CE[Ra1]_F(KR)_PF1(SC_SS)_PFA(SHU)_PN(SHU).pdf |
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