Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Originally described to be involved in feeding regulation, orexins/hypocretins are now also considered as major regulatory actors of numerous biological processes, such as pain, sleep, cardiovascular function, neuroendocrine regulation, and energy expenditure. Therefore, they constitute one of the m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00830/full |
| _version_ | 1818992689107959808 |
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| author | Edward Milbank Edward Milbank Miguel López Miguel López |
| author_facet | Edward Milbank Edward Milbank Miguel López Miguel López |
| author_sort | Edward Milbank |
| collection | DOAJ |
| description | Originally described to be involved in feeding regulation, orexins/hypocretins are now also considered as major regulatory actors of numerous biological processes, such as pain, sleep, cardiovascular function, neuroendocrine regulation, and energy expenditure. Therefore, they constitute one of the most pleiotropic families of hypothalamic neuropeptides. Although their orexigenic effect is well documented, orexins/hypocretins also exert central effects on energy expenditure, notably on the brown adipose tissue (BAT) thermogenesis. A better comprehension of the underlying mechanisms and potential interactions with other hypothalamic molecular pathways involved in the modulation of food intake and thermogenesis, such as AMP-activated protein kinase (AMPK) and endoplasmic reticulum (ER) stress, is essential to determine the exact implication and pathophysiological relevance of orexins/hypocretins on the control of energy balance. Here, we will review the actions of orexins on energy balance, with special focus on feeding and brown fat function. |
| first_indexed | 2024-12-20T20:30:09Z |
| format | Article |
| id | doaj.art-51aaa6b0fd454a8baf08ca020b1be281 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T20:30:09Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-51aaa6b0fd454a8baf08ca020b1be2812022-12-21T19:27:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-12-011010.3389/fendo.2019.00830436541Orexins/Hypocretins: Key Regulators of Energy HomeostasisEdward Milbank0Edward Milbank1Miguel López2Miguel López3Department of Physiology, CIMUS, Instituto de Investigación Sanitaria, Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainDepartment of Physiology, CIMUS, Instituto de Investigación Sanitaria, Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainOriginally described to be involved in feeding regulation, orexins/hypocretins are now also considered as major regulatory actors of numerous biological processes, such as pain, sleep, cardiovascular function, neuroendocrine regulation, and energy expenditure. Therefore, they constitute one of the most pleiotropic families of hypothalamic neuropeptides. Although their orexigenic effect is well documented, orexins/hypocretins also exert central effects on energy expenditure, notably on the brown adipose tissue (BAT) thermogenesis. A better comprehension of the underlying mechanisms and potential interactions with other hypothalamic molecular pathways involved in the modulation of food intake and thermogenesis, such as AMP-activated protein kinase (AMPK) and endoplasmic reticulum (ER) stress, is essential to determine the exact implication and pathophysiological relevance of orexins/hypocretins on the control of energy balance. Here, we will review the actions of orexins on energy balance, with special focus on feeding and brown fat function.https://www.frontiersin.org/article/10.3389/fendo.2019.00830/fullorexins/hypocretinshypothalamusfood intakethermogenesisbrown adipose tissue |
| spellingShingle | Edward Milbank Edward Milbank Miguel López Miguel López Orexins/Hypocretins: Key Regulators of Energy Homeostasis Frontiers in Endocrinology orexins/hypocretins hypothalamus food intake thermogenesis brown adipose tissue |
| title | Orexins/Hypocretins: Key Regulators of Energy Homeostasis |
| title_full | Orexins/Hypocretins: Key Regulators of Energy Homeostasis |
| title_fullStr | Orexins/Hypocretins: Key Regulators of Energy Homeostasis |
| title_full_unstemmed | Orexins/Hypocretins: Key Regulators of Energy Homeostasis |
| title_short | Orexins/Hypocretins: Key Regulators of Energy Homeostasis |
| title_sort | orexins hypocretins key regulators of energy homeostasis |
| topic | orexins/hypocretins hypothalamus food intake thermogenesis brown adipose tissue |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00830/full |
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