Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution
Candida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in clinical settings, owing to the inefficacy of current antifungals in modulating virulence, development of resistance, and poor penetration into the biofilm matrix. Various predisposition factors are molecular driv...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1245808/full |
| _version_ | 1797660640621363200 |
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| author | Helma David Adline Princy Solomon |
| author_facet | Helma David Adline Princy Solomon |
| author_sort | Helma David |
| collection | DOAJ |
| description | Candida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in clinical settings, owing to the inefficacy of current antifungals in modulating virulence, development of resistance, and poor penetration into the biofilm matrix. Various predisposition factors are molecular drivers that lead to the dysbiosis of normal microflora of the vagina, upregulation of central metabolic pathways, morphogenesis, hyphal extension, adhesion, invasion, and biofilm formation leading to chronic infection and recurrence. Hence, it is crucial to understand the molecular mechanism behind the virulence pathways driven by those drivers to decode the drug targets. Finding innovative solutions targeting fungal virulence/biofilm may potentiate the antifungals at low concentrations without affecting the recurrence of resistance. With this background, the present review details the critical molecular drivers and associated network of virulence pathways, possible drug targets, target-specific inhibitors, and probable mode of drug delivery to cross the preclinical phase by appropriate in vivo models. |
| first_indexed | 2024-03-11T18:33:51Z |
| format | Article |
| id | doaj.art-51aaeee806b645c79b350d0c5b892c02 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T18:33:51Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-51aaeee806b645c79b350d0c5b892c022023-10-13T07:37:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-10-011310.3389/fcimb.2023.12458081245808Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solutionHelma DavidAdline Princy SolomonCandida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in clinical settings, owing to the inefficacy of current antifungals in modulating virulence, development of resistance, and poor penetration into the biofilm matrix. Various predisposition factors are molecular drivers that lead to the dysbiosis of normal microflora of the vagina, upregulation of central metabolic pathways, morphogenesis, hyphal extension, adhesion, invasion, and biofilm formation leading to chronic infection and recurrence. Hence, it is crucial to understand the molecular mechanism behind the virulence pathways driven by those drivers to decode the drug targets. Finding innovative solutions targeting fungal virulence/biofilm may potentiate the antifungals at low concentrations without affecting the recurrence of resistance. With this background, the present review details the critical molecular drivers and associated network of virulence pathways, possible drug targets, target-specific inhibitors, and probable mode of drug delivery to cross the preclinical phase by appropriate in vivo models.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1245808/fullC. albicansvaginal candidiasispredisposition factorsmorphogenesismultidrug resistancepossible drug targets |
| spellingShingle | Helma David Adline Princy Solomon Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution Frontiers in Cellular and Infection Microbiology C. albicans vaginal candidiasis predisposition factors morphogenesis multidrug resistance possible drug targets |
| title | Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution |
| title_full | Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution |
| title_fullStr | Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution |
| title_full_unstemmed | Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution |
| title_short | Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution |
| title_sort | molecular association of candida albicans and vulvovaginal candidiasis focusing on a solution |
| topic | C. albicans vaginal candidiasis predisposition factors morphogenesis multidrug resistance possible drug targets |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1245808/full |
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