CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA
Background: To improve differential diagnosis of chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), identification of new biological markers is needed. Aim: To differentiate between COPD and BA using modern immunological methods. Materials and methods: Surface markers of periphe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
MONIKI
2016-02-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
| Subjects: | |
| Online Access: | https://www.almclinmed.ru/jour/article/view/173 |
| Summary: | Background: To improve differential diagnosis of chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA), identification of new biological markers is needed. Aim: To differentiate between COPD and BA using modern immunological methods. Materials and methods: Surface markers of peripheral blood lymphocytes were studied in patients with COPD (n=37) and BA (n=49) exacerbation. Immunological status was also assessed in 24 healthy controls. Results: In both COPD and BA, typical inflammatory changes of T-lymphocytes, B-lymphocytes and NK-cells counts were found. Lymphocyte surface phenotype changes were significantly different in COPD and BA. In COPD, a significant elevation of blood cytotoxic T-lymphocytes (CD8+) up to 34% was demonstrated; on the contrary, in BA patients, cytotoxic T-lymphocytes (CD8+) decreased to 21%. CD16+ lymphocytes (NK-cells) were significantly increased (up to 33%) in COPD patients and corresponded to normal values in BA (~10%). Conclusion: Differences in biological markers in COPD and BA reflect distinct pathogenesis of the diseases and may be used for differential diagnosis. |
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| ISSN: | 2072-0505 2587-9294 |