Superior Intrinsic Mitochondrial Respiration in Women Than in Men
Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50mito) in relation to biolo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01133/full |
| _version_ | 1818341014868328448 |
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| author | Daniele A. Cardinale Filip J. Larsen Tomas A. Schiffer David Morales-Alamo David Morales-Alamo Björn Ekblom Jose A. L. Calbet Jose A. L. Calbet Jose A. L. Calbet Hans-Christer Holmberg Hans-Christer Holmberg Robert Boushel |
| author_facet | Daniele A. Cardinale Filip J. Larsen Tomas A. Schiffer David Morales-Alamo David Morales-Alamo Björn Ekblom Jose A. L. Calbet Jose A. L. Calbet Jose A. L. Calbet Hans-Christer Holmberg Hans-Christer Holmberg Robert Boushel |
| author_sort | Daniele A. Cardinale |
| collection | DOAJ |
| description | Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50mito) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating complex I (CIP) and complex I+II (CI+IIP) (p < 0.05), and was similar to trained men (CIP, p = 0.053; CI+IIP, p = 0.066). Proton leak and p50mito were higher in women compared to men independent of VO2max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p50mito exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise. |
| first_indexed | 2024-12-13T15:52:04Z |
| format | Article |
| id | doaj.art-51aececfc6fc4bde8493bfea0ffa9144 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T15:52:04Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-51aececfc6fc4bde8493bfea0ffa91442022-12-21T23:39:26ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-08-01910.3389/fphys.2018.01133384898Superior Intrinsic Mitochondrial Respiration in Women Than in MenDaniele A. Cardinale0Filip J. Larsen1Tomas A. Schiffer2David Morales-Alamo3David Morales-Alamo4Björn Ekblom5Jose A. L. Calbet6Jose A. L. Calbet7Jose A. L. Calbet8Hans-Christer Holmberg9Hans-Christer Holmberg10Robert Boushel11Åstrand Laboratory, The Swedish School of Sport and Health Sciences, Stockholm, SwedenÅstrand Laboratory, The Swedish School of Sport and Health Sciences, Stockholm, SwedenDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SwedenDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas, SpainResearch Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Gran Canaria, SpainÅstrand Laboratory, The Swedish School of Sport and Health Sciences, Stockholm, SwedenDepartment of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas, SpainResearch Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Gran Canaria, SpainSchool of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, CanadaSchool of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, CanadaSwedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, SwedenSchool of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, CanadaSexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50mito) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating complex I (CIP) and complex I+II (CI+IIP) (p < 0.05), and was similar to trained men (CIP, p = 0.053; CI+IIP, p = 0.066). Proton leak and p50mito were higher in women compared to men independent of VO2max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p50mito exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise.https://www.frontiersin.org/article/10.3389/fphys.2018.01133/fullsexual dimorphismmitochondriaendurance performancemitochondrial functionskeletal muscleOXPHOS |
| spellingShingle | Daniele A. Cardinale Filip J. Larsen Tomas A. Schiffer David Morales-Alamo David Morales-Alamo Björn Ekblom Jose A. L. Calbet Jose A. L. Calbet Jose A. L. Calbet Hans-Christer Holmberg Hans-Christer Holmberg Robert Boushel Superior Intrinsic Mitochondrial Respiration in Women Than in Men Frontiers in Physiology sexual dimorphism mitochondria endurance performance mitochondrial function skeletal muscle OXPHOS |
| title | Superior Intrinsic Mitochondrial Respiration in Women Than in Men |
| title_full | Superior Intrinsic Mitochondrial Respiration in Women Than in Men |
| title_fullStr | Superior Intrinsic Mitochondrial Respiration in Women Than in Men |
| title_full_unstemmed | Superior Intrinsic Mitochondrial Respiration in Women Than in Men |
| title_short | Superior Intrinsic Mitochondrial Respiration in Women Than in Men |
| title_sort | superior intrinsic mitochondrial respiration in women than in men |
| topic | sexual dimorphism mitochondria endurance performance mitochondrial function skeletal muscle OXPHOS |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01133/full |
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