Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy
Introduction: Nontuberculous mycobacteria (NTM) may be present in the respiratory tract of patients with lung cancer. We investigated the association of pulmonary NTM with the clinical features and outcomes of patients with lung cancer. Methods: Between 2015 and 2019, the data of patients diagnosed...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S168411822200192X |
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| author | Ting-Yu Liao Jann-Yuan Wang Jin-Yuan Shih |
| author_facet | Ting-Yu Liao Jann-Yuan Wang Jin-Yuan Shih |
| author_sort | Ting-Yu Liao |
| collection | DOAJ |
| description | Introduction: Nontuberculous mycobacteria (NTM) may be present in the respiratory tract of patients with lung cancer. We investigated the association of pulmonary NTM with the clinical features and outcomes of patients with lung cancer. Methods: Between 2015 and 2019, the data of patients diagnosed with lung cancer at a medical center in northern Taiwan were analyzed. Patients whose respiratory specimens were culture-positive for NTM were identified (NTM group). For each patient in the NTM group, a matched control was selected (control group). The survival of the two groups was compared using the Kaplan–Meier method and Cox proportional hazards regression analysis. Results: Among 8718 patients with lung cancer, 5418 (62.1%) underwent a sputum mycobacterial culture. At least one NTM species was isolated from 138 (2.5%) patients. The median age was 72 years (range: 64–80). In the NTM group, 19.8% fulfilled both the microbiological and radiographic criteria for the diagnosis of NTM lung disease. Compared with the control group, the NTM group exhibited a lower body mass index (22.4 vs. 23.6, p = 0.025) and a higher prevalence of structural lung disease (38.9% vs. 22.2%, p = 0.004). The two-year survival was not significantly different between the two groups (hazard ratio [HR]: 1.110; 95% confidence interval [CI]: 0.702–1.754, p = 0.656). In patients receiving chemotherapy, pulmonary NTM was associated with worse survival (HR: 2.497, 95% CI: 1.262–4.943, p = 0.009). Conclusions: Except in patients receiving chemotherapy, pulmonary NTM may not be clinically relevant in patients with lung cancer. |
| first_indexed | 2024-04-10T00:17:50Z |
| format | Article |
| id | doaj.art-51af01bf401e49b9b18b4fdd40cd997d |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-10T00:17:50Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-51af01bf401e49b9b18b4fdd40cd997d2023-03-16T05:03:28ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822023-04-01562392399Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapyTing-Yu Liao0Jann-Yuan Wang1Jin-Yuan Shih2Department of Internal Medicine, National Taiwan University Hospital Hsin-chu Branch, National Taiwan University College of Medicine, Hsin-chu, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. No. 7, Chung-Shan South Road, Taipei 100225, Taiwan.Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanIntroduction: Nontuberculous mycobacteria (NTM) may be present in the respiratory tract of patients with lung cancer. We investigated the association of pulmonary NTM with the clinical features and outcomes of patients with lung cancer. Methods: Between 2015 and 2019, the data of patients diagnosed with lung cancer at a medical center in northern Taiwan were analyzed. Patients whose respiratory specimens were culture-positive for NTM were identified (NTM group). For each patient in the NTM group, a matched control was selected (control group). The survival of the two groups was compared using the Kaplan–Meier method and Cox proportional hazards regression analysis. Results: Among 8718 patients with lung cancer, 5418 (62.1%) underwent a sputum mycobacterial culture. At least one NTM species was isolated from 138 (2.5%) patients. The median age was 72 years (range: 64–80). In the NTM group, 19.8% fulfilled both the microbiological and radiographic criteria for the diagnosis of NTM lung disease. Compared with the control group, the NTM group exhibited a lower body mass index (22.4 vs. 23.6, p = 0.025) and a higher prevalence of structural lung disease (38.9% vs. 22.2%, p = 0.004). The two-year survival was not significantly different between the two groups (hazard ratio [HR]: 1.110; 95% confidence interval [CI]: 0.702–1.754, p = 0.656). In patients receiving chemotherapy, pulmonary NTM was associated with worse survival (HR: 2.497, 95% CI: 1.262–4.943, p = 0.009). Conclusions: Except in patients receiving chemotherapy, pulmonary NTM may not be clinically relevant in patients with lung cancer.http://www.sciencedirect.com/science/article/pii/S168411822200192XNontuberculous mycobacteriaLung cancerChemotherapy |
| spellingShingle | Ting-Yu Liao Jann-Yuan Wang Jin-Yuan Shih Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy Journal of Microbiology, Immunology and Infection Nontuberculous mycobacteria Lung cancer Chemotherapy |
| title | Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy |
| title_full | Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy |
| title_fullStr | Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy |
| title_full_unstemmed | Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy |
| title_short | Association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer: A retrospective matched cohort study with a special emphasis on the impact of chemotherapy |
| title_sort | association of pulmonary nontuberculous mycobacteria with the outcomes of patients with lung cancer a retrospective matched cohort study with a special emphasis on the impact of chemotherapy |
| topic | Nontuberculous mycobacteria Lung cancer Chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S168411822200192X |
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