Histone Variants: Guardians of Genome Integrity
Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/11/2424 |
| _version_ | 1797548739686039552 |
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| author | Juliette Ferrand Beatrice Rondinelli Sophie E. Polo |
| author_facet | Juliette Ferrand Beatrice Rondinelli Sophie E. Polo |
| author_sort | Juliette Ferrand |
| collection | DOAJ |
| description | Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field. |
| first_indexed | 2024-03-10T15:03:56Z |
| format | Article |
| id | doaj.art-51afcb598cfe49ce9e2dba62f4889c5b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:03:56Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-51afcb598cfe49ce9e2dba62f4889c5b2023-11-20T19:54:20ZengMDPI AGCells2073-44092020-11-01911242410.3390/cells9112424Histone Variants: Guardians of Genome IntegrityJuliette Ferrand0Beatrice Rondinelli1Sophie E. Polo2Epigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris, 75013 Paris, FranceEpigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris, 75013 Paris, FranceEpigenetics & Cell Fate Centre, UMR7216 CNRS, Université de Paris, 75013 Paris, FranceChromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer. Building on these findings, in this review, we discuss how histone variants and their associated chaperones safeguard genome stability and protect against tumorigenesis. Accumulating evidence supports the contribution of histone variants and their chaperones to the maintenance of chromosomal integrity and to various steps of the DNA damage response, including damaged chromatin dynamics, DNA damage repair, and damage-dependent transcription regulation. We present our current knowledge on these topics and review recent advances in deciphering how alterations in histone variant sequence, expression, and deposition into chromatin fuel oncogenic transformation by impacting cell proliferation and cell fate transitions. We also highlight open questions and upcoming challenges in this rapidly growing field.https://www.mdpi.com/2073-4409/9/11/2424cancercell fatechromatinchromosome integrityDNA damage responseDNA repair |
| spellingShingle | Juliette Ferrand Beatrice Rondinelli Sophie E. Polo Histone Variants: Guardians of Genome Integrity Cells cancer cell fate chromatin chromosome integrity DNA damage response DNA repair |
| title | Histone Variants: Guardians of Genome Integrity |
| title_full | Histone Variants: Guardians of Genome Integrity |
| title_fullStr | Histone Variants: Guardians of Genome Integrity |
| title_full_unstemmed | Histone Variants: Guardians of Genome Integrity |
| title_short | Histone Variants: Guardians of Genome Integrity |
| title_sort | histone variants guardians of genome integrity |
| topic | cancer cell fate chromatin chromosome integrity DNA damage response DNA repair |
| url | https://www.mdpi.com/2073-4409/9/11/2424 |
| work_keys_str_mv | AT julietteferrand histonevariantsguardiansofgenomeintegrity AT beatricerondinelli histonevariantsguardiansofgenomeintegrity AT sophieepolo histonevariantsguardiansofgenomeintegrity |