Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease
Background: The association between physical activity (PA) and arterial stiffness is particularly important in children with congenital heart disease (CHD) who are at risk for arterial stiffening. The aim of this study was to examine the association between objectively measured PA and arterial stiff...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/15/3266 |
| _version_ | 1797525441321369600 |
|---|---|
| author | Laura Willinger Leon Brudy Renate Oberhoffer-Fritz Peter Ewert Jan Müller |
| author_facet | Laura Willinger Leon Brudy Renate Oberhoffer-Fritz Peter Ewert Jan Müller |
| author_sort | Laura Willinger |
| collection | DOAJ |
| description | Background: The association between physical activity (PA) and arterial stiffness is particularly important in children with congenital heart disease (CHD) who are at risk for arterial stiffening. The aim of this study was to examine the association between objectively measured PA and arterial stiffness in children and adolescents with CHD. Methods: In 387 children and adolescents with various CHD (12.2 ± 3.3 years; 162 girls) moderate-to-vigorous PA (MVPA) was assessed with the “Garmin vivofit jr.” for 7 consecutive days. Arterial stiffness parameters including pulse wave velocity (PWV) and central systolic blood pressure (cSBP) were non-invasively assessed by oscillometric measurement via Mobil-O-Graph<sup>®</sup>. Results: MVPA was not associated with PWV (ß = −0.025, <i>p</i> = 0.446) and cSBP (ß = −0.020, <i>p</i> = 0.552) in children with CHD after adjusting for age, sex, BMI z-score, peripheral systolic blood pressure, heart rate and hypertensive agents. Children with CHD were remarkably active with 80% of the study population reaching the WHO recommendation of average 60 min of MVPA per day. Arterial stiffness did not differ between low-active and high-active CHD group after adjusting for age, sex, BMI z-score, peripheral systolic blood pressure, heart rate and hypertensive agents (PWV: F = 0.530, <i>p</i> = 0.467; cSBP: F = 0.843, <i>p</i> = 0.359). Conclusion: In this active cohort, no association between PA and arterial stiffness was found. Longer exposure to the respective risk factors of physical inactivity might be necessary to determine an impact of PA on the vascular system. |
| first_indexed | 2024-03-10T09:13:56Z |
| format | Article |
| id | doaj.art-51afdee3d2944842b4167063ad5a20f8 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:13:56Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-51afdee3d2944842b4167063ad5a20f82023-11-22T05:48:16ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015326610.3390/jcm10153266Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart DiseaseLaura Willinger0Leon Brudy1Renate Oberhoffer-Fritz2Peter Ewert3Jan Müller4Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, 80636 München, GermanyDepartment of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, 80636 München, GermanyDepartment of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, 80636 München, GermanyDepartment of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, 80636 München, GermanyDepartment of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, 80636 München, GermanyBackground: The association between physical activity (PA) and arterial stiffness is particularly important in children with congenital heart disease (CHD) who are at risk for arterial stiffening. The aim of this study was to examine the association between objectively measured PA and arterial stiffness in children and adolescents with CHD. Methods: In 387 children and adolescents with various CHD (12.2 ± 3.3 years; 162 girls) moderate-to-vigorous PA (MVPA) was assessed with the “Garmin vivofit jr.” for 7 consecutive days. Arterial stiffness parameters including pulse wave velocity (PWV) and central systolic blood pressure (cSBP) were non-invasively assessed by oscillometric measurement via Mobil-O-Graph<sup>®</sup>. Results: MVPA was not associated with PWV (ß = −0.025, <i>p</i> = 0.446) and cSBP (ß = −0.020, <i>p</i> = 0.552) in children with CHD after adjusting for age, sex, BMI z-score, peripheral systolic blood pressure, heart rate and hypertensive agents. Children with CHD were remarkably active with 80% of the study population reaching the WHO recommendation of average 60 min of MVPA per day. Arterial stiffness did not differ between low-active and high-active CHD group after adjusting for age, sex, BMI z-score, peripheral systolic blood pressure, heart rate and hypertensive agents (PWV: F = 0.530, <i>p</i> = 0.467; cSBP: F = 0.843, <i>p</i> = 0.359). Conclusion: In this active cohort, no association between PA and arterial stiffness was found. Longer exposure to the respective risk factors of physical inactivity might be necessary to determine an impact of PA on the vascular system.https://www.mdpi.com/2077-0383/10/15/3266physical activityarterial stiffnesschildren with congenital heart disease |
| spellingShingle | Laura Willinger Leon Brudy Renate Oberhoffer-Fritz Peter Ewert Jan Müller Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease Journal of Clinical Medicine physical activity arterial stiffness children with congenital heart disease |
| title | Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease |
| title_full | Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease |
| title_fullStr | Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease |
| title_full_unstemmed | Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease |
| title_short | Association between Objectively Measured Physical Activity and Arterial Stiffness in Children with Congenital Heart Disease |
| title_sort | association between objectively measured physical activity and arterial stiffness in children with congenital heart disease |
| topic | physical activity arterial stiffness children with congenital heart disease |
| url | https://www.mdpi.com/2077-0383/10/15/3266 |
| work_keys_str_mv | AT laurawillinger associationbetweenobjectivelymeasuredphysicalactivityandarterialstiffnessinchildrenwithcongenitalheartdisease AT leonbrudy associationbetweenobjectivelymeasuredphysicalactivityandarterialstiffnessinchildrenwithcongenitalheartdisease AT renateoberhofferfritz associationbetweenobjectivelymeasuredphysicalactivityandarterialstiffnessinchildrenwithcongenitalheartdisease AT peterewert associationbetweenobjectivelymeasuredphysicalactivityandarterialstiffnessinchildrenwithcongenitalheartdisease AT janmuller associationbetweenobjectivelymeasuredphysicalactivityandarterialstiffnessinchildrenwithcongenitalheartdisease |