Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits
As an important part of the circadian rhythm, the circadian regulation factor 2 of cryptochrome (<i>CRY2</i>), regulates many physiological functions. Previous studies have reported that <i>CRY2</i> is involved in growth and development. However, the relationship between <...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2076-2615/12/13/1616 |
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| author | Xuelan Li Enhui Jiang Kejing Zhang Sihuan Zhang Fugui Jiang Enliang Song Hong Chen Peng Guo Xianyong Lan |
| author_facet | Xuelan Li Enhui Jiang Kejing Zhang Sihuan Zhang Fugui Jiang Enliang Song Hong Chen Peng Guo Xianyong Lan |
| author_sort | Xuelan Li |
| collection | DOAJ |
| description | As an important part of the circadian rhythm, the circadian regulation factor 2 of cryptochrome (<i>CRY2</i>), regulates many physiological functions. Previous studies have reported that <i>CRY2</i> is involved in growth and development. However, the relationship between <i>CRY2</i> gene polymorphism and cattle carcass traits remains unclear. The aim of this study was to detect the possible variations of the <i>CRY2</i> gene and elucidate the association between the <i>CRY2</i> gene and carcass traits in the Shandong Black Cattle Genetic Resource (SDBCGR) population (<i>n</i> = 705). We identified a 24-bp deletion variation (<i>CRY2</i>-P6) and a 6-bp insertion variation (<i>CRY2</i>-P7) in the bovine <i>CRY2</i> gene. The frequency of the homozygous II genotype is higher than the heterozygous ID genotype in both two loci. In addition, <i>CRY2</i>-P6 was consistent with HWE (<i>p</i> > 0.05). Importantly, the <i>CRY2</i>-P6 variant was significantly associated with 12 carcass traits, including gross weight, ribeye, high rib, thick flank, etc. and the II was the dominant genotype. The <i>CRY2</i>-P7 site was also significantly correlated with five traits (gross weight, beef-tongue, etc.). Collectively, these outcomes indicated that the two Indel loci in the <i>CRY2</i> gene could be used for marker-assisted selection of cattle carcass traits. |
| first_indexed | 2024-03-09T22:11:16Z |
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| language | English |
| last_indexed | 2024-03-09T22:11:16Z |
| publishDate | 2022-06-01 |
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| series | Animals |
| spelling | doaj.art-51b0cb1ed8184daabd1ec47e983abb8c2023-11-23T19:31:57ZengMDPI AGAnimals2076-26152022-06-011213161610.3390/ani12131616Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass TraitsXuelan Li0Enhui Jiang1Kejing Zhang2Sihuan Zhang3Fugui Jiang4Enliang Song5Hong Chen6Peng Guo7Xianyong Lan8Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaInstitute of Animal Science and Veterinary, Shandong Academy of Agriculture Science, Jinan 250100, ChinaInstitute of Animal Science and Veterinary, Shandong Academy of Agriculture Science, Jinan 250100, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaCollege of Computer and Information Engineering, Tianjin Agricultural University, Tianjin 300380, ChinaKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, ChinaAs an important part of the circadian rhythm, the circadian regulation factor 2 of cryptochrome (<i>CRY2</i>), regulates many physiological functions. Previous studies have reported that <i>CRY2</i> is involved in growth and development. However, the relationship between <i>CRY2</i> gene polymorphism and cattle carcass traits remains unclear. The aim of this study was to detect the possible variations of the <i>CRY2</i> gene and elucidate the association between the <i>CRY2</i> gene and carcass traits in the Shandong Black Cattle Genetic Resource (SDBCGR) population (<i>n</i> = 705). We identified a 24-bp deletion variation (<i>CRY2</i>-P6) and a 6-bp insertion variation (<i>CRY2</i>-P7) in the bovine <i>CRY2</i> gene. The frequency of the homozygous II genotype is higher than the heterozygous ID genotype in both two loci. In addition, <i>CRY2</i>-P6 was consistent with HWE (<i>p</i> > 0.05). Importantly, the <i>CRY2</i>-P6 variant was significantly associated with 12 carcass traits, including gross weight, ribeye, high rib, thick flank, etc. and the II was the dominant genotype. The <i>CRY2</i>-P7 site was also significantly correlated with five traits (gross weight, beef-tongue, etc.). Collectively, these outcomes indicated that the two Indel loci in the <i>CRY2</i> gene could be used for marker-assisted selection of cattle carcass traits.https://www.mdpi.com/2076-2615/12/13/1616cattle<i>CRY2</i>indelcarcass traitsassociation |
| spellingShingle | Xuelan Li Enhui Jiang Kejing Zhang Sihuan Zhang Fugui Jiang Enliang Song Hong Chen Peng Guo Xianyong Lan Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits Animals cattle <i>CRY2</i> indel carcass traits association |
| title | Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits |
| title_full | Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits |
| title_fullStr | Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits |
| title_full_unstemmed | Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits |
| title_short | Genetic Variations within the Bovine <i>CRY2</i> Gene Are Significantly Associated with Carcass Traits |
| title_sort | genetic variations within the bovine i cry2 i gene are significantly associated with carcass traits |
| topic | cattle <i>CRY2</i> indel carcass traits association |
| url | https://www.mdpi.com/2076-2615/12/13/1616 |
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