Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions
ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2020-05-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100600&tlng=pt |
| _version_ | 1819006438640451584 |
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| author | Raylane P Gomes Gabriela Tayrine Caetano Lucas Henrique F Sampaio Camila R Silva Maurício B Costa Maria Auxiliadora Cysneiro Isabela Jubé Wastowski |
| author_facet | Raylane P Gomes Gabriela Tayrine Caetano Lucas Henrique F Sampaio Camila R Silva Maurício B Costa Maria Auxiliadora Cysneiro Isabela Jubé Wastowski |
| author_sort | Raylane P Gomes |
| collection | DOAJ |
| description | ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis. |
| first_indexed | 2024-12-21T00:08:41Z |
| format | Article |
| id | doaj.art-51b0ee0260b14ee3b837c0a4dda4a5a3 |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-12-21T00:08:41Z |
| publishDate | 2020-05-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-51b0ee0260b14ee3b837c0a4dda4a5a32022-12-21T19:22:24ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742020-05-015610.5935/1676-2444.20200016Evaluation of HLA-G immune checkpoint molecule in melanocytic lesionsRaylane P GomesGabriela Tayrine CaetanoLucas Henrique F SampaioCamila R SilvaMaurício B CostaMaria Auxiliadora CysneiroIsabela Jubé Wastowskihttps://orcid.org/0000-0001-5441-4186ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100600&tlng=ptmelanomaHLA-G antigensimmunohistochemistry |
| spellingShingle | Raylane P Gomes Gabriela Tayrine Caetano Lucas Henrique F Sampaio Camila R Silva Maurício B Costa Maria Auxiliadora Cysneiro Isabela Jubé Wastowski Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions Jornal Brasileiro de Patologia e Medicina Laboratorial melanoma HLA-G antigens immunohistochemistry |
| title | Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_full | Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_fullStr | Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_full_unstemmed | Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_short | Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_sort | evaluation of hla g immune checkpoint molecule in melanocytic lesions |
| topic | melanoma HLA-G antigens immunohistochemistry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100600&tlng=pt |
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