Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines

Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines

Leukocyte cell-surface HLA-I molecules, involved in antigen presentation of peptides to CD8+ T-cells, consist of a heavy chain (HC) non-covalently linked to β2-microglobulin (β2m) (Face-1). The HC amino acid composition varies across all six isoforms of HLA-I, while that of β2m remains the same. Eac...

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Bibliographic Details
Main Authors: Mepur H. Ravindranath, Narendranath M. Ravindranath, Senthamil R. Selvan, Edward J. Filippone, Carly J. Amato-Menker, Fatiha El Hilali
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Vaccines
Subjects:
HLA
heavy chain
α1 and α2 helices
β2microglobulin
monomeric
homodimers
Online Access:https://www.mdpi.com/2076-393X/10/2/339

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