Reference panel guided topological structure annotation of Hi-C data
Predicting topological structures from Hi-C data provides insight into comprehending gene expression and regulation. Here, the authors present RefHiC, an attention-based deep learning framework that leverages a reference panel of Hi-C datasets to assist topological structure annotation from a given...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35231-3 |
| _version_ | 1811207738606223360 |
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| author | Yanlin Zhang Mathieu Blanchette |
| author_facet | Yanlin Zhang Mathieu Blanchette |
| author_sort | Yanlin Zhang |
| collection | DOAJ |
| description | Predicting topological structures from Hi-C data provides insight into comprehending gene expression and regulation. Here, the authors present RefHiC, an attention-based deep learning framework that leverages a reference panel of Hi-C datasets to assist topological structure annotation from a given study sample. |
| first_indexed | 2024-04-12T04:09:38Z |
| format | Article |
| id | doaj.art-51b3fddd600a4de99e9d42ad3959ed31 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T04:09:38Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-51b3fddd600a4de99e9d42ad3959ed312022-12-22T03:48:32ZengNature PortfolioNature Communications2041-17232022-12-0113111210.1038/s41467-022-35231-3Reference panel guided topological structure annotation of Hi-C dataYanlin Zhang0Mathieu Blanchette1School of Computer Science, McGill UniversitySchool of Computer Science, McGill UniversityPredicting topological structures from Hi-C data provides insight into comprehending gene expression and regulation. Here, the authors present RefHiC, an attention-based deep learning framework that leverages a reference panel of Hi-C datasets to assist topological structure annotation from a given study sample.https://doi.org/10.1038/s41467-022-35231-3 |
| spellingShingle | Yanlin Zhang Mathieu Blanchette Reference panel guided topological structure annotation of Hi-C data Nature Communications |
| title | Reference panel guided topological structure annotation of Hi-C data |
| title_full | Reference panel guided topological structure annotation of Hi-C data |
| title_fullStr | Reference panel guided topological structure annotation of Hi-C data |
| title_full_unstemmed | Reference panel guided topological structure annotation of Hi-C data |
| title_short | Reference panel guided topological structure annotation of Hi-C data |
| title_sort | reference panel guided topological structure annotation of hi c data |
| url | https://doi.org/10.1038/s41467-022-35231-3 |
| work_keys_str_mv | AT yanlinzhang referencepanelguidedtopologicalstructureannotationofhicdata AT mathieublanchette referencepanelguidedtopologicalstructureannotationofhicdata |