Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors
The dopaminergic system is known to be involved in working memory processed by several brain regions like prefrontal cortex (PFC), hippocampus, striatum. In an earlier study we could show that Levodopa but not Modafinil enhanced working memory in a T-maze only during the early phase of training (day...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00196/full |
| _version_ | 1811258958982152192 |
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| author | Mekite Bezu Jovana Maliković Martina Kristofova Ephrem Engidawork Harald Höger Gert Lubec Volker Korz |
| author_facet | Mekite Bezu Jovana Maliković Martina Kristofova Ephrem Engidawork Harald Höger Gert Lubec Volker Korz |
| author_sort | Mekite Bezu |
| collection | DOAJ |
| description | The dopaminergic system is known to be involved in working memory processed by several brain regions like prefrontal cortex (PFC), hippocampus, striatum. In an earlier study we could show that Levodopa but not Modafinil enhanced working memory in a T-maze only during the early phase of training (day 3), whereas the later phase remained unaffected. Rats treated with a higher dose performed better than low dose treated rats. Here we could more specifically segregate the contributions of dopamine type 1- and 2- like receptors (D1R; D2R) to the training state dependent modulation of spatial working memory by intracerebroventricular (ICV) application of a D1R-like (SKF81297) and D2R-like agonist (Sumanirole) and antagonist (SCH23390, Remoxipride) at a low and high dose through 3 days of training. The D1R-like-agonist at both doses enhanced working memory at day 1 but only in the low dose treated rats enhancement persists over training compared to control rats. Rats treated with a high dose of a D1R-like-antagonist show persistent enhancement of working memory over training, whereas in low dose treated rats no statistical difference at any time point could be determined compared to controls. The D2R-like-agonist at both doses does not show an effect at any time point when compared to control animals, whereas the D2R-like antagonist at a low dose enhanced working memory at day 2. For the most effective D1R-like agonist, we repeated the experiments in a water maze working memory task, to test for task dependent differences in working memory modulations. Treated rats at both doses did not differ as compared to controls, but the temporal behavioral performance of all groups was different compared to T-maze trained rats. The results are in line with the view that spatial working memory is optimized within a limited range of dopaminergic transmission, however suggest that these ranges vary during spatial training. |
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| format | Article |
| id | doaj.art-51b549a59beb4a72994b479264c13b77 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-12T18:23:24Z |
| publishDate | 2017-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-51b549a59beb4a72994b479264c13b772022-12-22T03:21:21ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532017-10-011110.3389/fnbeh.2017.00196283310Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like ReceptorsMekite Bezu0Jovana Maliković1Martina Kristofova2Ephrem Engidawork3Harald Höger4Gert Lubec5Volker Korz6Department of Pediatrics, Medical University of Vienna, Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Vienna, AustriaSchool of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCore Unit of Biomedical Research, Division of Laboratory Animal Science and Genetics, Department of Biomedicine, Medical University of Vienna, Vienna, AustriaParacelsus Medical University, Salzburg, AustriaBrain Research Center, Medical University of Vienna, Vienna, AustriaThe dopaminergic system is known to be involved in working memory processed by several brain regions like prefrontal cortex (PFC), hippocampus, striatum. In an earlier study we could show that Levodopa but not Modafinil enhanced working memory in a T-maze only during the early phase of training (day 3), whereas the later phase remained unaffected. Rats treated with a higher dose performed better than low dose treated rats. Here we could more specifically segregate the contributions of dopamine type 1- and 2- like receptors (D1R; D2R) to the training state dependent modulation of spatial working memory by intracerebroventricular (ICV) application of a D1R-like (SKF81297) and D2R-like agonist (Sumanirole) and antagonist (SCH23390, Remoxipride) at a low and high dose through 3 days of training. The D1R-like-agonist at both doses enhanced working memory at day 1 but only in the low dose treated rats enhancement persists over training compared to control rats. Rats treated with a high dose of a D1R-like-antagonist show persistent enhancement of working memory over training, whereas in low dose treated rats no statistical difference at any time point could be determined compared to controls. The D2R-like-agonist at both doses does not show an effect at any time point when compared to control animals, whereas the D2R-like antagonist at a low dose enhanced working memory at day 2. For the most effective D1R-like agonist, we repeated the experiments in a water maze working memory task, to test for task dependent differences in working memory modulations. Treated rats at both doses did not differ as compared to controls, but the temporal behavioral performance of all groups was different compared to T-maze trained rats. The results are in line with the view that spatial working memory is optimized within a limited range of dopaminergic transmission, however suggest that these ranges vary during spatial training.http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00196/fullcognitiondopamine receptor D1dopamine receptor D2T-Mazeworking memorywater maze |
| spellingShingle | Mekite Bezu Jovana Maliković Martina Kristofova Ephrem Engidawork Harald Höger Gert Lubec Volker Korz Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors Frontiers in Behavioral Neuroscience cognition dopamine receptor D1 dopamine receptor D2 T-Maze working memory water maze |
| title | Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors |
| title_full | Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors |
| title_fullStr | Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors |
| title_full_unstemmed | Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors |
| title_short | Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors |
| title_sort | spatial working memory in male rats pre experience and task dependent roles of dopamine d1 and d2 like receptors |
| topic | cognition dopamine receptor D1 dopamine receptor D2 T-Maze working memory water maze |
| url | http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00196/full |
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