Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations
The aim of this study was to develop a fast method for estimating whether a brain volume loss is within the normal range for the respective age of the patient.A readout-segmented diffusion weighted EPI sequence was performed as part of the routine examination at a 3T scanner. Data without (B0-image)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00078/full |
| _version_ | 1819298644006797312 |
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| author | Uwe eKlose Marion eBatra Thomas eNägele |
| author_facet | Uwe eKlose Marion eBatra Thomas eNägele |
| author_sort | Uwe eKlose |
| collection | DOAJ |
| description | The aim of this study was to develop a fast method for estimating whether a brain volume loss is within the normal range for the respective age of the patient.A readout-segmented diffusion weighted EPI sequence was performed as part of the routine examination at a 3T scanner. Data without (B0-image) and with diffusion weighting (1000 s/mm2) from 492 patients were examined. 173 data sets had to be excluded due to brain lesions or to pathological enlarged CSF spaces. In the remaining 319 data sets, ADC values were calculated for all pixels exceeding a combined threshold in the diffusion weighted data and in the non-diffusion weighted data. The first part of the histogram represents pixels containing mostly brain tissue. The percentage of number of pixels in this part of the ADC histograms was evaluated for all patients and was correlated with the age of the patients.In all the areas examined, a monotone change of relative pixel numbers with the age of the patients was found. The reduction of the contribution of pixels containing mostly brain tissue accelerated with age and was found to be 0.18%/year in the age of 20, 0.34%/year in the age of 50, and 0.50%/year in the age of 80.The observed decrease of voxel from brain tissue with increasing age corresponds to previously published results based on more time-consuming 3-D measurements. The presented technique uses a conventional clinical sequence and might be helpful in deciding whether an observed brain volume loss in a patient is within the normal range for the age of the patient. |
| first_indexed | 2024-12-24T05:33:10Z |
| format | Article |
| id | doaj.art-51b55ed23e774ba4bd09c3f48c830e8b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-24T05:33:10Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-51b55ed23e774ba4bd09c3f48c830e8b2022-12-21T17:13:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652013-11-01510.3389/fnagi.2013.0007862753Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinationsUwe eKlose0Marion eBatra1Thomas eNägele2University Hospital of TübingenUniversity Hospital of TübingenUniversity Hospital of TübingenThe aim of this study was to develop a fast method for estimating whether a brain volume loss is within the normal range for the respective age of the patient.A readout-segmented diffusion weighted EPI sequence was performed as part of the routine examination at a 3T scanner. Data without (B0-image) and with diffusion weighting (1000 s/mm2) from 492 patients were examined. 173 data sets had to be excluded due to brain lesions or to pathological enlarged CSF spaces. In the remaining 319 data sets, ADC values were calculated for all pixels exceeding a combined threshold in the diffusion weighted data and in the non-diffusion weighted data. The first part of the histogram represents pixels containing mostly brain tissue. The percentage of number of pixels in this part of the ADC histograms was evaluated for all patients and was correlated with the age of the patients.In all the areas examined, a monotone change of relative pixel numbers with the age of the patients was found. The reduction of the contribution of pixels containing mostly brain tissue accelerated with age and was found to be 0.18%/year in the age of 20, 0.34%/year in the age of 50, and 0.50%/year in the age of 80.The observed decrease of voxel from brain tissue with increasing age corresponds to previously published results based on more time-consuming 3-D measurements. The presented technique uses a conventional clinical sequence and might be helpful in deciding whether an observed brain volume loss in a patient is within the normal range for the age of the patient.http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00078/fullAtrophyCerebrospinal FluidMagnetic Resonance ImagingDiffusion Weighted ImagingDiffusion-weightingBrain tissue volume loss |
| spellingShingle | Uwe eKlose Marion eBatra Thomas eNägele Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations Frontiers in Aging Neuroscience Atrophy Cerebrospinal Fluid Magnetic Resonance Imaging Diffusion Weighted Imaging Diffusion-weighting Brain tissue volume loss |
| title | Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations |
| title_full | Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations |
| title_fullStr | Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations |
| title_full_unstemmed | Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations |
| title_short | Age-dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations |
| title_sort | age dependent changes in the global histogram of apparent diffusion coefficients values in magnetic resonance brain examinations |
| topic | Atrophy Cerebrospinal Fluid Magnetic Resonance Imaging Diffusion Weighted Imaging Diffusion-weighting Brain tissue volume loss |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00078/full |
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