EP2 inhibition restores myeloid metabolism and reverses cognitive decline
Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E2 is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829323000073 |
| _version_ | 1797828113769431040 |
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| author | Ryan Lushington, MS Samuel Camilli Francisco Pascual, BS Richard F. Lockey, MD Narasaiah Kolliputi, PhD |
| author_facet | Ryan Lushington, MS Samuel Camilli Francisco Pascual, BS Richard F. Lockey, MD Narasaiah Kolliputi, PhD |
| author_sort | Ryan Lushington, MS |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E2 is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E2 receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target. |
| first_indexed | 2024-04-09T12:59:43Z |
| format | Article |
| id | doaj.art-51b5a89e8949476c865bb6f2c906d1ab |
| institution | Directory Open Access Journal |
| issn | 2772-8293 |
| language | English |
| last_indexed | 2024-04-09T12:59:43Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj.art-51b5a89e8949476c865bb6f2c906d1ab2023-05-13T04:26:07ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932023-05-0122100082EP2 inhibition restores myeloid metabolism and reverses cognitive declineRyan Lushington, MS0Samuel Camilli1Francisco Pascual, BS2Richard F. Lockey, MD3Narasaiah Kolliputi, PhD4Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, TampaDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, TampaDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, TampaDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, TampaCorresponding author: Narasaiah Kolliputi, PhD, Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL 33612.; Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, TampaNonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E2 is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E2 receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target.http://www.sciencedirect.com/science/article/pii/S2772829323000073PGE2 signalingEP2prostaglandin E2cognitive declinetumorigenesismyeloid metabolism |
| spellingShingle | Ryan Lushington, MS Samuel Camilli Francisco Pascual, BS Richard F. Lockey, MD Narasaiah Kolliputi, PhD EP2 inhibition restores myeloid metabolism and reverses cognitive decline Journal of Allergy and Clinical Immunology: Global PGE2 signaling EP2 prostaglandin E2 cognitive decline tumorigenesis myeloid metabolism |
| title | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
| title_full | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
| title_fullStr | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
| title_full_unstemmed | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
| title_short | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
| title_sort | ep2 inhibition restores myeloid metabolism and reverses cognitive decline |
| topic | PGE2 signaling EP2 prostaglandin E2 cognitive decline tumorigenesis myeloid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2772829323000073 |
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