EP2 inhibition restores myeloid metabolism and reverses cognitive decline

EP2 inhibition restores myeloid metabolism and reverses cognitive decline

Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E2 is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlat...

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Bibliographic Details
Main Authors: Ryan Lushington, MS, Samuel Camilli, Francisco Pascual, BS, Richard F. Lockey, MD, Narasaiah Kolliputi, PhD
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
PGE2 signaling
EP2
prostaglandin E2
cognitive decline
tumorigenesis
myeloid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829323000073

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