Role of Post-Translational Modifications in Colorectal Cancer Metastasis
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. CRC metastasis is a multi-step process with various factors involved, including genetic and epigenetic regulations, which turn out to be a serious threat to CRC patients. Post-translational modifications (PTMs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/3/652 |
| _version_ | 1797318924908363776 |
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| author | Na Peng Jingwei Liu Shuangshuang Hai Yihong Liu Haibo Zhao Weixin Liu |
| author_facet | Na Peng Jingwei Liu Shuangshuang Hai Yihong Liu Haibo Zhao Weixin Liu |
| author_sort | Na Peng |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. CRC metastasis is a multi-step process with various factors involved, including genetic and epigenetic regulations, which turn out to be a serious threat to CRC patients. Post-translational modifications (PTMs) of proteins involve the addition of chemical groups, sugars, or proteins to specific residues, which fine-tunes a protein’s stability, localization, or interactions to orchestrate complicated biological processes. An increasing number of recent studies suggest that dysregulation of PTMs, such as phosphorylation, ubiquitination, and glycosylation, play pivotal roles in the CRC metastasis cascade. Here, we summarized recent advances in the role of post-translational modifications in diverse aspects of CRC metastasis and its detailed molecular mechanisms. Moreover, advances in drugs targeting PTMs and their cooperation with other anti-cancer drugs, which might provide novel targets for CRC treatment and improve therapeutic efficacy, were also discussed. |
| first_indexed | 2024-03-08T03:59:30Z |
| format | Article |
| id | doaj.art-51b7f71c04f64df1bd540d787d28c1b0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T03:59:30Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-51b7f71c04f64df1bd540d787d28c1b02024-02-09T15:09:28ZengMDPI AGCancers2072-66942024-02-0116365210.3390/cancers16030652Role of Post-Translational Modifications in Colorectal Cancer MetastasisNa Peng0Jingwei Liu1Shuangshuang Hai2Yihong Liu3Haibo Zhao4Weixin Liu5Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Anus and Intestine Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaColorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. CRC metastasis is a multi-step process with various factors involved, including genetic and epigenetic regulations, which turn out to be a serious threat to CRC patients. Post-translational modifications (PTMs) of proteins involve the addition of chemical groups, sugars, or proteins to specific residues, which fine-tunes a protein’s stability, localization, or interactions to orchestrate complicated biological processes. An increasing number of recent studies suggest that dysregulation of PTMs, such as phosphorylation, ubiquitination, and glycosylation, play pivotal roles in the CRC metastasis cascade. Here, we summarized recent advances in the role of post-translational modifications in diverse aspects of CRC metastasis and its detailed molecular mechanisms. Moreover, advances in drugs targeting PTMs and their cooperation with other anti-cancer drugs, which might provide novel targets for CRC treatment and improve therapeutic efficacy, were also discussed.https://www.mdpi.com/2072-6694/16/3/652colorectal cancermetastasispost-translational modificationstherapy |
| spellingShingle | Na Peng Jingwei Liu Shuangshuang Hai Yihong Liu Haibo Zhao Weixin Liu Role of Post-Translational Modifications in Colorectal Cancer Metastasis Cancers colorectal cancer metastasis post-translational modifications therapy |
| title | Role of Post-Translational Modifications in Colorectal Cancer Metastasis |
| title_full | Role of Post-Translational Modifications in Colorectal Cancer Metastasis |
| title_fullStr | Role of Post-Translational Modifications in Colorectal Cancer Metastasis |
| title_full_unstemmed | Role of Post-Translational Modifications in Colorectal Cancer Metastasis |
| title_short | Role of Post-Translational Modifications in Colorectal Cancer Metastasis |
| title_sort | role of post translational modifications in colorectal cancer metastasis |
| topic | colorectal cancer metastasis post-translational modifications therapy |
| url | https://www.mdpi.com/2072-6694/16/3/652 |
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