Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02148/full |
| _version_ | 1819210945126203392 |
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| author | Ana Rodríguez-Galán Ana Rodríguez-Galán Lola Fernández-Messina Lola Fernández-Messina Francisco Sánchez-Madrid Francisco Sánchez-Madrid Francisco Sánchez-Madrid |
| author_facet | Ana Rodríguez-Galán Ana Rodríguez-Galán Lola Fernández-Messina Lola Fernández-Messina Francisco Sánchez-Madrid Francisco Sánchez-Madrid Francisco Sánchez-Madrid |
| author_sort | Ana Rodríguez-Galán |
| collection | DOAJ |
| description | MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. |
| first_indexed | 2024-12-23T06:19:14Z |
| format | Article |
| id | doaj.art-51bbb49f73a948138f873faeb098a772 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T06:19:14Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-51bbb49f73a948138f873faeb098a7722022-12-21T17:57:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02148414634Control of Immunoregulatory Molecules by miRNAs in T Cell ActivationAna Rodríguez-Galán0Ana Rodríguez-Galán1Lola Fernández-Messina2Lola Fernández-Messina3Francisco Sánchez-Madrid4Francisco Sánchez-Madrid5Francisco Sánchez-Madrid6Servicio de Inmunología, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares, Madrid, SpainServicio de Inmunología, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares, Madrid, SpainServicio de Inmunología, Instituto de Investigación Sanitaria Princesa (IP), Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Madrid, SpainMiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.https://www.frontiersin.org/article/10.3389/fimmu.2018.02148/fullT cell activationmicroRNAs (miRNAs)immunoregulatory moleculesmiRNA signatureCD4CD8 |
| spellingShingle | Ana Rodríguez-Galán Ana Rodríguez-Galán Lola Fernández-Messina Lola Fernández-Messina Francisco Sánchez-Madrid Francisco Sánchez-Madrid Francisco Sánchez-Madrid Control of Immunoregulatory Molecules by miRNAs in T Cell Activation Frontiers in Immunology T cell activation microRNAs (miRNAs) immunoregulatory molecules miRNA signature CD4 CD8 |
| title | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation |
| title_full | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation |
| title_fullStr | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation |
| title_full_unstemmed | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation |
| title_short | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation |
| title_sort | control of immunoregulatory molecules by mirnas in t cell activation |
| topic | T cell activation microRNAs (miRNAs) immunoregulatory molecules miRNA signature CD4 CD8 |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02148/full |
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