A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults
BackgroundTreatment-resistant depression (TRD) may have different physiopathological neuromechanism in different age groups. This study used the amplitude of low frequency fluctuations (ALFF) to initially compare abnormalities in local functional brain activity in younger and older patients with TRD...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.949698/full |
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| author | Jifei Sun Chunlei Guo Yue Ma Zhongming Du Zhi Wang Yi Luo Limei Chen Deqiang Gao Xiaojiao Li Ke Xu Yang Hong Xue Yu Xue Xiao Jiliang Fang Yong Liu |
| author_facet | Jifei Sun Chunlei Guo Yue Ma Zhongming Du Zhi Wang Yi Luo Limei Chen Deqiang Gao Xiaojiao Li Ke Xu Yang Hong Xue Yu Xue Xiao Jiliang Fang Yong Liu |
| author_sort | Jifei Sun |
| collection | DOAJ |
| description | BackgroundTreatment-resistant depression (TRD) may have different physiopathological neuromechanism in different age groups. This study used the amplitude of low frequency fluctuations (ALFF) to initially compare abnormalities in local functional brain activity in younger and older patients with TRD.Materials and methodsA total of 21 older TRD patients, 19 younger TRD, 19 older healthy controls (HCs), and 19 younger HCs underwent resting-state functional MRI scans, and the images were analyzed using the ALFF and further analyzed for correlation between abnormal brain regions and clinical symptoms in TRD patients of different age groups.ResultsCompared with the older TRD, the younger TRD group had increased ALFF in the left middle frontal gyrus and decreased ALFF in the left caudate nucleus. Compared with the matched HC group, ALFF was increased in the right middle temporal gyrus and left pallidum in the older TRD group, whereas no significant differences were found in the younger TRD group. In addition, ALFF values in the left middle frontal gyrus in the younger TRD group and in the right middle temporal gyrus in the older TRD were both positively correlated with the 17-item Hamilton Rating Scale for Depression score.ConclusionDifferent neuropathological mechanisms may exist in TRD patients of different ages, especially in the left middle frontal gyrus and left caudate nucleus. This study is beneficial in providing potential key targets for the clinical management of TRD patients of different ages. |
| first_indexed | 2024-04-13T01:48:22Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T01:48:22Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-51bc2edcdbec468082f4fcf4cc439cb82022-12-22T03:07:57ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-08-011610.3389/fnins.2022.949698949698A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adultsJifei Sun0Chunlei Guo1Yue Ma2Zhongming Du3Zhi Wang4Yi Luo5Limei Chen6Deqiang Gao7Xiaojiao Li8Ke Xu9Yang Hong10Xue Yu11Xue Xiao12Jiliang Fang13Yong Liu14Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing First Hospital of Integrated Chinese and Western Medicine, Beijing, ChinaBeijing First Hospital of Integrated Chinese and Western Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaAffiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, ChinaBackgroundTreatment-resistant depression (TRD) may have different physiopathological neuromechanism in different age groups. This study used the amplitude of low frequency fluctuations (ALFF) to initially compare abnormalities in local functional brain activity in younger and older patients with TRD.Materials and methodsA total of 21 older TRD patients, 19 younger TRD, 19 older healthy controls (HCs), and 19 younger HCs underwent resting-state functional MRI scans, and the images were analyzed using the ALFF and further analyzed for correlation between abnormal brain regions and clinical symptoms in TRD patients of different age groups.ResultsCompared with the older TRD, the younger TRD group had increased ALFF in the left middle frontal gyrus and decreased ALFF in the left caudate nucleus. Compared with the matched HC group, ALFF was increased in the right middle temporal gyrus and left pallidum in the older TRD group, whereas no significant differences were found in the younger TRD group. In addition, ALFF values in the left middle frontal gyrus in the younger TRD group and in the right middle temporal gyrus in the older TRD were both positively correlated with the 17-item Hamilton Rating Scale for Depression score.ConclusionDifferent neuropathological mechanisms may exist in TRD patients of different ages, especially in the left middle frontal gyrus and left caudate nucleus. This study is beneficial in providing potential key targets for the clinical management of TRD patients of different ages.https://www.frontiersin.org/articles/10.3389/fnins.2022.949698/fulltreatment-resistant depression (TRD)amplitude of low-frequency fluctuationMRImajor depressive disorder (MDD)age |
| spellingShingle | Jifei Sun Chunlei Guo Yue Ma Zhongming Du Zhi Wang Yi Luo Limei Chen Deqiang Gao Xiaojiao Li Ke Xu Yang Hong Xue Yu Xue Xiao Jiliang Fang Yong Liu A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults Frontiers in Neuroscience treatment-resistant depression (TRD) amplitude of low-frequency fluctuation MRI major depressive disorder (MDD) age |
| title | A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults |
| title_full | A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults |
| title_fullStr | A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults |
| title_full_unstemmed | A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults |
| title_short | A comparative study of amplitude of low-frequence fluctuation of resting-state fMRI between the younger and older treatment-resistant depression in adults |
| title_sort | comparative study of amplitude of low frequence fluctuation of resting state fmri between the younger and older treatment resistant depression in adults |
| topic | treatment-resistant depression (TRD) amplitude of low-frequency fluctuation MRI major depressive disorder (MDD) age |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.949698/full |
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