Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1- or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between Jan...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-05-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867013000573 |
| _version_ | 1819159843353657344 |
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| author | Renata Maronna Praça Longhi Verônica Marques Zembrzuski Paulo Cesar Basta Julio Croda |
| author_facet | Renata Maronna Praça Longhi Verônica Marques Zembrzuski Paulo Cesar Basta Julio Croda |
| author_sort | Renata Maronna Praça Longhi |
| collection | DOAJ |
| description | We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1- or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-α, IL-12p40 and IFN-γ production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease. Keywords: Tuberculosis, Immune response, Indigenous populations, Polymorphism |
| first_indexed | 2024-12-22T16:47:00Z |
| format | Article |
| id | doaj.art-51bf1e3029b1453690c755fc52f57c02 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-22T16:47:00Z |
| publishDate | 2013-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-51bf1e3029b1453690c755fc52f57c022022-12-21T18:19:43ZengElsevierBrazilian Journal of Infectious Diseases1413-86702013-05-01173363368Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief reviewRenata Maronna Praça Longhi0Verônica Marques Zembrzuski1Paulo Cesar Basta2Julio Croda3Faculty of Health Sciences, Universidade Federal da Grande Dourados (UFGD), Dourados, MS, BrazilHuman Genetics Laboratory, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil; Health Sciences School, Universidade do Grande Rio (UNIGRANRIO), Duque de Caxias, RJ, BrazilEscola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, BrazilFaculty of Health Sciences, Universidade Federal da Grande Dourados (UFGD), Dourados, MS, Brazil; Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil; Corresponding author at: Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Rodovia Dourados, Itaúm, km 12, Dourados, MT 79804-970, Brazil.We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1- or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-α, IL-12p40 and IFN-γ production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease. Keywords: Tuberculosis, Immune response, Indigenous populations, Polymorphismhttp://www.sciencedirect.com/science/article/pii/S1413867013000573 |
| spellingShingle | Renata Maronna Praça Longhi Verônica Marques Zembrzuski Paulo Cesar Basta Julio Croda Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review Brazilian Journal of Infectious Diseases |
| title | Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review |
| title_full | Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review |
| title_fullStr | Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review |
| title_full_unstemmed | Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review |
| title_short | Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review |
| title_sort | genetic polymorphism and immune response to tuberculosis in indigenous populations a brief review |
| url | http://www.sciencedirect.com/science/article/pii/S1413867013000573 |
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