Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

Cells that experience high levels of oxidative stress respond by inducing antioxidant proteins through activation of the protein transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is negatively regulated by the E3 ubiquitin ligase Kelch-like ECH-associated protein 1 (Keap1...

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Bibliographic Details
Main Authors: Vy Ngo, Nadun C. Karunatilleke, Anne Brickenden, Wing-Yiu Choy, Martin L. Duennwald
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
Nrf2
Keap1
oxidation
oxidative stress
protein misfolding
Online Access:https://www.mdpi.com/2076-3921/11/2/243

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