MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES
Abstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/399 |
| _version_ | 1797198085842010112 |
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| author | A. Il’inskaya L. Pichugina N. Oliferuk V. L’vov B. Pinegin |
| author_facet | A. Il’inskaya L. Pichugina N. Oliferuk V. L’vov B. Pinegin |
| author_sort | A. Il’inskaya |
| collection | DOAJ |
| description | Abstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human macrophages exposed to muramyl peptides showed the increasing expression of costimulatory receptors and antigen presenting molecules. On the other hand, there was downregulation of receptors involved in recognition and engulfing of microorganism. In response to bacterial component macrophages secreted several cytokines: IL–12, TNFα, IL–6. (Med. Immunol., 2005, vol.7, № 1, pp. 21526) |
| first_indexed | 2024-03-08T05:50:36Z |
| format | Article |
| id | doaj.art-51c0f8b8d81b4c429ab9c7acdfb8bac4 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:15Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-51c0f8b8d81b4c429ab9c7acdfb8bac42024-04-22T13:07:36ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0171212610.15789/1563-0625-2005-1-21-26396MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDESA. Il’inskaya0L. Pichugina1N. Oliferuk2V. L’vov3B. Pinegin4ГНЦ — Институт иммунологии МЗ РФ, МоскваГНЦ — Институт иммунологии МЗ РФ, МоскваГНЦ — Институт иммунологии МЗ РФ, МоскваГНЦ — Институт иммунологии МЗ РФ, МоскваГНЦ — Институт иммунологии МЗ РФ, МоскваAbstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human macrophages exposed to muramyl peptides showed the increasing expression of costimulatory receptors and antigen presenting molecules. On the other hand, there was downregulation of receptors involved in recognition and engulfing of microorganism. In response to bacterial component macrophages secreted several cytokines: IL–12, TNFα, IL–6. (Med. Immunol., 2005, vol.7, № 1, pp. 21526)https://www.mimmun.ru/mimmun/article/view/399macrophagesmuramyl peptidesmaturationil_12, tnfαil_6phagocytosisbactericidal activity |
| spellingShingle | A. Il’inskaya L. Pichugina N. Oliferuk V. L’vov B. Pinegin MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES Медицинская иммунология macrophages muramyl peptides maturation il_12, tnfα il_6 phagocytosis bactericidal activity |
| title | MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES |
| title_full | MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES |
| title_fullStr | MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES |
| title_full_unstemmed | MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES |
| title_short | MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES |
| title_sort | maturation of macrophages under the influence of muramyl peptides |
| topic | macrophages muramyl peptides maturation il_12, tnfα il_6 phagocytosis bactericidal activity |
| url | https://www.mimmun.ru/mimmun/article/view/399 |
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