Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts
Introduction: The aim of the current analysis was to judge the hypoglycemic action of the phyto-extracts of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana using suitable in vitro approaches. Methods: The hypoglycemic activity of the phyto-material extracts was evaluated by employing var...
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Shahrekord University of Medical Sciences
2019-01-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://herbmedpharmacol.com/PDF/jhp-1261 |
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| author | Dheeraj S. Randive Mangesh A. Bhutkar Somnath D. Bhinge Kiran P. Shejawal Poonam R. Sanap Pranoti D. Patil Suhas A. Mane |
| author_facet | Dheeraj S. Randive Mangesh A. Bhutkar Somnath D. Bhinge Kiran P. Shejawal Poonam R. Sanap Pranoti D. Patil Suhas A. Mane |
| author_sort | Dheeraj S. Randive |
| collection | DOAJ |
| description | Introduction: The aim of the current analysis was to judge the hypoglycemic action of the phyto-extracts of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana using suitable in vitro approaches. Methods: The hypoglycemic activity of the phyto-material extracts was evaluated by employing various in-vitro methods namely glucose diffusion, amylolysis kinetics and glucose adsorption capacity. Results: The extracts of L. siceraria, C. dactylon and S. rebaudiana exhibited glucose dialysis retardation indices (GDRI) of 48.14%, 37.03% and 29.62%, respectively at 60 minutes which were reduced to 15.78%, 10.52% and 18.42%, respectively at 120 minutes. All the plant extracts used in the study adsorbed glucose and their adsorptions markedly enhanced with increase in sugar concentration. Conclusion: From the outcome of the assay it can be concluded that the extracts of L. siceraria, C. dactylon and S. rebaudiana have hypoglycemic activity as observed in various in-vitro assays. However, the beneficial actions require to be verified by adopting various in vivo techniques along with clinical trials for their efficient use as potential remedial moiety. |
| first_indexed | 2024-04-11T16:31:17Z |
| format | Article |
| id | doaj.art-51c2ff21aea141e5879eec451b8122aa |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-11T16:31:17Z |
| publishDate | 2019-01-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-51c2ff21aea141e5879eec451b8122aa2022-12-22T04:14:00ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042019-01-0181515510.15171/jhp.2019.09jhp-1261Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extractsDheeraj S. Randive0Mangesh A. Bhutkar1Somnath D. Bhinge2Kiran P. Shejawal3Poonam R. Sanap4Pranoti D. Patil5Suhas A. Mane6Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaRajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaRajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaRajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaRajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaRajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaRajarambapu College of Pharmacy, Kasegaon, Dist- Sangli,-415404, State – Maharashtra, IndiaIntroduction: The aim of the current analysis was to judge the hypoglycemic action of the phyto-extracts of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana using suitable in vitro approaches. Methods: The hypoglycemic activity of the phyto-material extracts was evaluated by employing various in-vitro methods namely glucose diffusion, amylolysis kinetics and glucose adsorption capacity. Results: The extracts of L. siceraria, C. dactylon and S. rebaudiana exhibited glucose dialysis retardation indices (GDRI) of 48.14%, 37.03% and 29.62%, respectively at 60 minutes which were reduced to 15.78%, 10.52% and 18.42%, respectively at 120 minutes. All the plant extracts used in the study adsorbed glucose and their adsorptions markedly enhanced with increase in sugar concentration. Conclusion: From the outcome of the assay it can be concluded that the extracts of L. siceraria, C. dactylon and S. rebaudiana have hypoglycemic activity as observed in various in-vitro assays. However, the beneficial actions require to be verified by adopting various in vivo techniques along with clinical trials for their efficient use as potential remedial moiety.http://herbmedpharmacol.com/PDF/jhp-1261Hypoglycemic activity Herbal medicineLagenaria sicerariaCynodon dactylonStevia rebaudianaAmylolysis kinetic |
| spellingShingle | Dheeraj S. Randive Mangesh A. Bhutkar Somnath D. Bhinge Kiran P. Shejawal Poonam R. Sanap Pranoti D. Patil Suhas A. Mane Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts Journal of HerbMed Pharmacology Hypoglycemic activity Herbal medicine Lagenaria siceraria Cynodon dactylon Stevia rebaudiana Amylolysis kinetic |
| title | Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts |
| title_full | Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts |
| title_fullStr | Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts |
| title_full_unstemmed | Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts |
| title_short | Hypoglycemic effects of Lagenaria siceraria, Cynodon dactylon and Stevia rebaudiana extracts |
| title_sort | hypoglycemic effects of lagenaria siceraria cynodon dactylon and stevia rebaudiana extracts |
| topic | Hypoglycemic activity Herbal medicine Lagenaria siceraria Cynodon dactylon Stevia rebaudiana Amylolysis kinetic |
| url | http://herbmedpharmacol.com/PDF/jhp-1261 |
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