Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation
Endocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple signal transduction pathways. Together with enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system (ECS),...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-12-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01699/full |
| _version_ | 1818260108006653952 |
|---|---|
| author | Cyntia E. Abán Paula L. Accialini Tomás Etcheverry Gustavo F. Leguizamón Nora A. Martinez Nora A. Martinez Mariana G. Farina Mariana G. Farina |
| author_facet | Cyntia E. Abán Paula L. Accialini Tomás Etcheverry Gustavo F. Leguizamón Nora A. Martinez Nora A. Martinez Mariana G. Farina Mariana G. Farina |
| author_sort | Cyntia E. Abán |
| collection | DOAJ |
| description | Endocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple signal transduction pathways. Together with enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system (ECS), which is involved in different physiological processes in reproduction. The placenta, which is essential for the success of gestation and optimal fetal growth, undergoes constant tissue remodeling. ECS members are expressed in trophoblast cells, and current evidence suggests that this system is involved in placental development, apoptosis, and syncytialization. Impairment of endocannabinoid signaling has been associated with several pathological conditions such as intrauterine growth restriction and preeclampsia. Both clinical entities are characterized by dysregulation on vascular perfusion where nitrergic system performs a pivotal role. Nitric oxide (NO) is a potent local vasodepressor that exerts a critical role in the regulation of hemodynamic flow, contributing to the maintenance of low vascular resistance in the feto-placental circulation. NO production could be affected by different factors and growing evidence suggests that the endocannabinoid mediators may regulate nitrergic signaling. Herein, we review emerging knowledge supporting ECS-mediated regulation of NO production in normal placentation. Finally, we discuss how alterations in these systems could affect homoeostasis and contribute to the occurrence of placental-mediated pregnancy complications. Given the impact on women and perinatal heath, we will focus on current knowledge regarding the effects of ECS on nitrergic system in normal and pathological placentation. |
| first_indexed | 2024-12-12T18:26:05Z |
| format | Article |
| id | doaj.art-51c302afe051452cab7646524e89fd9c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T18:26:05Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-51c302afe051452cab7646524e89fd9c2022-12-22T00:16:01ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-12-01910.3389/fphys.2018.01699415861Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological PlacentationCyntia E. Abán0Paula L. Accialini1Tomás Etcheverry2Gustavo F. Leguizamón3Nora A. Martinez4Nora A. Martinez5Mariana G. Farina6Mariana G. Farina7Laboratorio de Investigación Aplicada a las Neurociencias (LIAN), FLENI – CONICET, Belén de Escobar, ArgentinaLaboratorio de Fisiopatología Placentaria, CEFyBO-UBA-CONICET, Buenos Aires, ArgentinaLaboratorio de Fisiopatología Placentaria, CEFyBO-UBA-CONICET, Buenos Aires, ArgentinaUnidad de Embarazo de Alto Riesgo, CEMIC, Buenos Aires, ArgentinaLaboratorio de Biología de la Reproducción, IFIBIO-UBA-CONICET, Buenos Aires, ArgentinaRed Iberoamericana de Alteraciones Vasculares Asociadas a Trastornos del Embarazo (RIVA-TREM), Buenos Aires, ArgentinaLaboratorio de Fisiopatología Placentaria, CEFyBO-UBA-CONICET, Buenos Aires, ArgentinaRed Iberoamericana de Alteraciones Vasculares Asociadas a Trastornos del Embarazo (RIVA-TREM), Buenos Aires, ArgentinaEndocannabinoids are a group of endogenous lipid mediators that act as ligands of cannabinoid and vanilloid receptors, activating multiple signal transduction pathways. Together with enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system (ECS), which is involved in different physiological processes in reproduction. The placenta, which is essential for the success of gestation and optimal fetal growth, undergoes constant tissue remodeling. ECS members are expressed in trophoblast cells, and current evidence suggests that this system is involved in placental development, apoptosis, and syncytialization. Impairment of endocannabinoid signaling has been associated with several pathological conditions such as intrauterine growth restriction and preeclampsia. Both clinical entities are characterized by dysregulation on vascular perfusion where nitrergic system performs a pivotal role. Nitric oxide (NO) is a potent local vasodepressor that exerts a critical role in the regulation of hemodynamic flow, contributing to the maintenance of low vascular resistance in the feto-placental circulation. NO production could be affected by different factors and growing evidence suggests that the endocannabinoid mediators may regulate nitrergic signaling. Herein, we review emerging knowledge supporting ECS-mediated regulation of NO production in normal placentation. Finally, we discuss how alterations in these systems could affect homoeostasis and contribute to the occurrence of placental-mediated pregnancy complications. Given the impact on women and perinatal heath, we will focus on current knowledge regarding the effects of ECS on nitrergic system in normal and pathological placentation.https://www.frontiersin.org/article/10.3389/fphys.2018.01699/fullplacentaendocannabinoidsnitric oxidepreeclampsiaendothelial disfunctionanandamide |
| spellingShingle | Cyntia E. Abán Paula L. Accialini Tomás Etcheverry Gustavo F. Leguizamón Nora A. Martinez Nora A. Martinez Mariana G. Farina Mariana G. Farina Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation Frontiers in Physiology placenta endocannabinoids nitric oxide preeclampsia endothelial disfunction anandamide |
| title | Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation |
| title_full | Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation |
| title_fullStr | Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation |
| title_full_unstemmed | Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation |
| title_short | Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation |
| title_sort | crosstalk between nitric oxide and endocannabinoid signaling pathways in normal and pathological placentation |
| topic | placenta endocannabinoids nitric oxide preeclampsia endothelial disfunction anandamide |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01699/full |
| work_keys_str_mv | AT cyntiaeaban crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT paulalaccialini crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT tomasetcheverry crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT gustavofleguizamon crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT noraamartinez crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT noraamartinez crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT marianagfarina crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation AT marianagfarina crosstalkbetweennitricoxideandendocannabinoidsignalingpathwaysinnormalandpathologicalplacentation |