DNA Methyltransferase Regulates Nitric Oxide Homeostasis and Virulence in a Chronically Adapted Pseudomonas aeruginosa Strain

DNA Methyltransferase Regulates Nitric Oxide Homeostasis and Virulence in a Chronically Adapted Pseudomonas aeruginosa Strain

ABSTRACT Opportunistic pathogens such as Pseudomonas aeruginosa adapt their genomes rapidly during chronic infections. Understanding their epigenetic regulation may provide biomarkers for diagnosis and reveal novel regulatory mechanisms. We performed single-molecule real-time sequencing (SMRT-seq) t...

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Bibliographic Details
Main Authors: Shuhong Han, Jihong Liu, Mianhuan Li, Yizhou Zhang, Xiangke Duan, Yingdan Zhang, Hao Chen, Zhao Cai, Liang Yang, Yang Liu
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mSystems
Subjects:
Pseudomonas aeruginosa
DNA methyltransferase
denitrification
virulence
bacterium-host interactions
DNA methylation
Online Access:https://journals.asm.org/doi/10.1128/msystems.00434-22

Internet

https://journals.asm.org/doi/10.1128/msystems.00434-22

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