Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases

Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases

Abstract Background In vivo assessment of neuroinflammation by 18-kDa translocator protein positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical and clinical research of neurodegenerative disorders. Higher TSPO-PET binding as a surrogate for microglial activation i...

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Main Authors: Gloria Biechele, Nicolai Franzmeier, Tanja Blume, Michael Ewers, Jose Medina Luque, Florian Eckenweber, Christian Sacher, Leonie Beyer, Francois Ruch-Rubinstein, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Paul Cumming, Peter Bartenstein, Axel Rominger, Günter U. Höglinger, Jochen Herms, Matthias Brendel
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Neuroinflammation
Subjects:
Sex
Microglia
TSPO
Amyloid
Tau
Online Access:https://doi.org/10.1186/s12974-020-02046-2

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