Protomer alignment modulates specificity of RNA substrate recognition by Ire1

Protomer alignment modulates specificity of RNA substrate recognition by Ire1

The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER). In metazoan cells, the Ire1 branch of the UPR initiates two functional outputs—non-conventional mRNA splicing and selective mRNA decay (RIDD). By contrast, Ire1 orthologs from Saccharomyces c...

Full description

Bibliographic Details
Main Authors:	Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, R Dyche Mullins, Matthew P Jacobson, Jirka Peschek, Peter Walter
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-04-01
Series:	eLife
Subjects:	unfolded protein response enzymatic substrate specificity RNA biology Ire1
Online Access:	https://elifesciences.org/articles/67425

Similar Items

An unfolded protein-induced conformational switch activates mammalian IRE1
by: G Elif Karagöz, et al.
Published: (2017-10-01)

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
by: Marta Carrara, et al.
Published: (2015-02-01)

Physiological roles of Regulated Ire1 Dependent Decay
by: Dina S. Coelho, et al.
Published: (2014-04-01)

Inositol Requiring Enzyme (IRE), a multiplayer in sensing endoplasmic reticulum stress
by: Zhixin Zhou, et al.
Published: (2021-11-01)

IRE1α Signaling Pathways Involved in Mammalian Cell Fate Determination
by: Jie Wu, et al.
Published: (2016-02-01)

Diverse Sphingolipid Species Harbor Different Effects on Ire1 Clustering
by: Mark A. Bieniawski, et al.
Published: (2022-10-01)

The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology
by: Mahmoud Aghaei, et al.
Published: (2021-09-01)

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity
by: Felipe Flores-Santibañez, et al.
Published: (2023-06-01)

IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases
by: Raghu Patil Junjappa, et al.
Published: (2018-06-01)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
by: Megan C Kopp, et al.
Published: (2018-01-01)

ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response
by: Richard H Chapple, et al.
Published: (2018-02-01)

Live imaging of the co-translational recruitment of XBP1 mRNA to the ER and its processing by diffuse, non-polarized IRE1α
by: Silvia Gómez-Puerta, et al.
Published: (2022-06-01)

The Unfolded Protein Response Sensor IRE1 Regulates Activation of In Vitro Differentiated Type 1 Conventional DCs with Viral Stimuli
by: Bernardita Medel, et al.
Published: (2023-06-01)

Teacher Performance Management in Improving Islamic Religious Education (IRE) Lesson Learning
by: Een Nurjannah, et al.
Published: (2021-08-01)

Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway
by: Anna Shishova, et al.
Published: (2022-11-01)

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
by: Diego Acosta-Alvear, et al.
Published: (2018-12-01)

The Avian Encephalomyelitis Virus (AEV) 5’ Untranslated Region Contains an IRES with Similarity to the Hepatitis C Virus IRES
by: M Bakhshesh, et al.
Published: (2005-10-01)

A Quantitative Arabidopsis IRE1a Ribonuclease-Dependent in vitro mRNA Cleavage Assay for Functional Studies of Substrate Splicing and Decay Activities
by: Danish Diwan, et al.
Published: (2021-07-01)

IRE1α Promotes Zika Virus Infection via XBP1
by: Elena P. Kolpikova, et al.
Published: (2020-03-01)

Ebola Virus Activates IRE1α-Dependent <i>XBP1u</i> Splicing
by: Cornelius Rohde, et al.
Published: (2022-12-01)

Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib
by: Yusuke Yamashita, et al.
Published: (2020-08-01)

Intense endoplasmic reticulum stress (ERS) / IRE1α enhanced Oxaliplatin efficacy by decreased ABCC10 in colorectal cancer cells
by: Xiaohui Liu, et al.
Published: (2022-12-01)

Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells
by: Po-Chun Hsieh, et al.
Published: (2022-06-01)

Dual IRE1 RNase functions dictate glioblastoma development
by: Stéphanie Lhomond, et al.
Published: (2018-03-01)

The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection
by: Yingxin Zhao, et al.
Published: (2022-08-01)

Real-Time and Non-invasive Monitoring of the Activation of the IRE1α-XBP1 Pathway in Individuals with Hemodynamic Impairment
by: Baptiste Fohlen, et al.
Published: (2018-01-01)

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay
by: Jirka Peschek, et al.
Published: (2019-06-01)

Advances and Breakthroughs in IRES-Directed Translation and Replication of Picornaviruses
by: Sahibzada Waheed Abdullah, et al.
Published: (2023-04-01)

Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis
by: Aseem Pandey, et al.
Published: (2018-04-01)

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1
by: Christopher J. Adams, et al.
Published: (2019-03-01)

Engineering ER-stress dependent non-conventional mRNA splicing
by: Weihan Li, et al.
Published: (2018-07-01)

Structural characterization of ribosome recruitment and translocation by type IV IRES
by: Jason Murray, et al.
Published: (2016-05-01)

A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate
by: Ritam Neupane, et al.
Published: (2020-04-01)

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
by: Natalia Siwecka, et al.
Published: (2021-02-01)

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells
by: Long C. Nguyen, et al.
Published: (2022-10-01)

KSHV Activates Unfolded Protein Response Sensors but Suppresses Downstream Transcriptional Responses to Support Lytic Replication
by: Benjamin P. Johnston, et al.
Published: (2020-07-01)

Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers
by: Manon Jaud, et al.
Published: (2020-02-01)

IRE1α Inhibitors as a Promising Therapeutic Strategy in Blood Malignancies
by: Wojciech Wiese, et al.
Published: (2022-05-01)

The Basic Concepts of Evaluation and Its Implementation in IRE Lessons in The Pandemic Era
by: Munaya Ulil Ilmi, et al.
Published: (2021-07-01)

Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch
by: Lena Krammes, et al.
Published: (2020-06-01)