In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS
The comparative analysis of 8 antigens of Mycobacterium tuberculosis (MPT83, MPT63, ESAT-6, CFP10, SodA, leuD, panD and HBHA) in silico to determine T-epitopes that can bind MHC class II molecules coding the most common in Eastern Europe HLA-DRB1 alleles was the goal of the work. The results show...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2013-12-01
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| Series: | Biotechnologia Acta |
| Subjects: | |
| Online Access: | http://biotechnology.kiev.ua/images/storage/6_2014/krinina.pdf |
| _version_ | 1797727993808814080 |
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| author | O. I. Krynina D. V. Kolibo S. V. Komisarenko |
| author_facet | O. I. Krynina D. V. Kolibo S. V. Komisarenko |
| author_sort | O. I. Krynina |
| collection | DOAJ |
| description | The comparative analysis of 8 antigens of Mycobacterium tuberculosis (MPT83, MPT63, ESAT-6, CFP10, SodA, leuD, panD and HBHA) in silico to determine T-epitopes that can bind MHC class II molecules coding the most common in Eastern Europe HLA-DRB1 alleles was the goal of the work.
The results show that the most immunogenic proteins are SodA, MPT83, leuD and MPT63, which has the largest number of T-epitopes for the alleles of interest. Accordingly, these antigens or their combinations could be promising candidates for development of new vaccines and diagnostics to form anti-TB immunity in Eastern European region and to determine the state of protection of the population. |
| first_indexed | 2024-03-12T11:07:26Z |
| format | Article |
| id | doaj.art-51c4db0f204c43849d5cf5e377d80cdb |
| institution | Directory Open Access Journal |
| issn | 2410-7751 2410-776X |
| language | English |
| last_indexed | 2024-03-12T11:07:26Z |
| publishDate | 2013-12-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | Biotechnologia Acta |
| spelling | doaj.art-51c4db0f204c43849d5cf5e377d80cdb2023-09-02T03:31:39ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryBiotechnologia Acta2410-77512410-776X2013-12-017691610.15407/biotech7.06.009In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINSO. I. Krynina0D. V. Kolibo1S. V. Komisarenko2Palladian Institute of Biochemistry of the National Academy of Sciences of Ukraine, KyivPalladian Institute of Biochemistry of the National Academy of Sciences of Ukraine, KyivPalladian Institute of Biochemistry of the National Academy of Sciences of Ukraine, KyivThe comparative analysis of 8 antigens of Mycobacterium tuberculosis (MPT83, MPT63, ESAT-6, CFP10, SodA, leuD, panD and HBHA) in silico to determine T-epitopes that can bind MHC class II molecules coding the most common in Eastern Europe HLA-DRB1 alleles was the goal of the work. The results show that the most immunogenic proteins are SodA, MPT83, leuD and MPT63, which has the largest number of T-epitopes for the alleles of interest. Accordingly, these antigens or their combinations could be promising candidates for development of new vaccines and diagnostics to form anti-TB immunity in Eastern European region and to determine the state of protection of the population.http://biotechnology.kiev.ua/images/storage/6_2014/krinina.pdfMycobacterium tuberculosisT-epitope |
| spellingShingle | O. I. Krynina D. V. Kolibo S. V. Komisarenko In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS Biotechnologia Acta Mycobacterium tuberculosis T-epitope |
| title | In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS |
| title_full | In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS |
| title_fullStr | In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS |
| title_full_unstemmed | In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS |
| title_short | In silico DETERMINATION OF T-EPITOPES OF Mycobacterium tuberculosis PROTEINS |
| title_sort | in silico determination of t epitopes of mycobacterium tuberculosis proteins |
| topic | Mycobacterium tuberculosis T-epitope |
| url | http://biotechnology.kiev.ua/images/storage/6_2014/krinina.pdf |
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