Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study
Background: Several pretreatment variables have been found to correlate with the clinical outcome of patients treated with NACT plus radical hysterectomy, such as FIGO stage, tumor size, and lymph node status. Methods: A single-center retrospective observational study to evaluate the use of NACT in...
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5207 |
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| author | Liliana Mereu Basilio Pecorino Martina Ferrara Venera Tomaselli Giuseppe Scibilia Paolo Scollo |
| author_facet | Liliana Mereu Basilio Pecorino Martina Ferrara Venera Tomaselli Giuseppe Scibilia Paolo Scollo |
| author_sort | Liliana Mereu |
| collection | DOAJ |
| description | Background: Several pretreatment variables have been found to correlate with the clinical outcome of patients treated with NACT plus radical hysterectomy, such as FIGO stage, tumor size, and lymph node status. Methods: A single-center retrospective observational study to evaluate the use of NACT in LACC, particularly in the lymph-node-positive subpopulation. The study, conducted at the Maternal and Child Department of “Cannizzaro Hospital” in Catania, included patients treated between 2009 and 2019. Multivariate analysis was performed to analyze responses to NACT according to clinicopathologic parameters. Kaplan–Meyer disease-free survival (DFS) and overall survival (OS) curves were generated according to different lymph node status subgroups. Results: A total of 151 consecutive patients were enrolled in the study. Significant independent risk factors for response to NACT were preoperative tumor diameter, parametrium involvement, and lymphoma vascular space invasion (LVSI). T initial diameter at NMR was found to be the independent prognostic predictor for general (<i>p</i> = 0.024) and lymph node (LND) response (<i>p</i> = 0.028). Tumors between 2 and 6 cm have a better response to NACT than tumors > 6 cm, and LVSI absence was an independent prognostic factor for LND response to NACT. Survival DFS and OS curves were significant for positive vs. negative pathologic LND. Conclusions: Neoadjuvant chemotherapy followed by surgery cannot be considered a standard of care in patients with locally advanced cervical cancer, particularly in the subgroup with pre-NACT imaging suspected for LND metastases. |
| first_indexed | 2024-03-11T11:32:32Z |
| format | Article |
| id | doaj.art-51c532a4efea4576b9729a66ae45be13 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T11:32:32Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-51c532a4efea4576b9729a66ae45be132023-11-10T15:00:14ZengMDPI AGCancers2072-66942023-10-011521520710.3390/cancers15215207Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center StudyLiliana Mereu0Basilio Pecorino1Martina Ferrara2Venera Tomaselli3Giuseppe Scibilia4Paolo Scollo5Obstetrics and Gynecology Unit, “G. Rodolico” University Hospital of Catania, CHIRMED Department, University of Catania, 95123 Catania, ItalyMaternal and Child Department, Obstetrics and Gynecology, Cannizzaro Hospital, 95100 Catania, ItalyMaternal and Child Department, Obstetrics and Gynecology, Cannizzaro Hospital, 95100 Catania, ItalyEconomics and Business Department, University of Catania, 95129 Catania, ItalyObstetrics and Gynecology, “Giovanni Paolo II” Hospital, 97100 Ragusa, ItalyMaternal and Child Department, Obstetrics and Gynecology, Cannizzaro Hospital, 95100 Catania, ItalyBackground: Several pretreatment variables have been found to correlate with the clinical outcome of patients treated with NACT plus radical hysterectomy, such as FIGO stage, tumor size, and lymph node status. Methods: A single-center retrospective observational study to evaluate the use of NACT in LACC, particularly in the lymph-node-positive subpopulation. The study, conducted at the Maternal and Child Department of “Cannizzaro Hospital” in Catania, included patients treated between 2009 and 2019. Multivariate analysis was performed to analyze responses to NACT according to clinicopathologic parameters. Kaplan–Meyer disease-free survival (DFS) and overall survival (OS) curves were generated according to different lymph node status subgroups. Results: A total of 151 consecutive patients were enrolled in the study. Significant independent risk factors for response to NACT were preoperative tumor diameter, parametrium involvement, and lymphoma vascular space invasion (LVSI). T initial diameter at NMR was found to be the independent prognostic predictor for general (<i>p</i> = 0.024) and lymph node (LND) response (<i>p</i> = 0.028). Tumors between 2 and 6 cm have a better response to NACT than tumors > 6 cm, and LVSI absence was an independent prognostic factor for LND response to NACT. Survival DFS and OS curves were significant for positive vs. negative pathologic LND. Conclusions: Neoadjuvant chemotherapy followed by surgery cannot be considered a standard of care in patients with locally advanced cervical cancer, particularly in the subgroup with pre-NACT imaging suspected for LND metastases.https://www.mdpi.com/2072-6694/15/21/5207cervical cancerneoadjuvant chemotherapyradical surgerylymph node responsedisease-free survivaloverall survival |
| spellingShingle | Liliana Mereu Basilio Pecorino Martina Ferrara Venera Tomaselli Giuseppe Scibilia Paolo Scollo Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study Cancers cervical cancer neoadjuvant chemotherapy radical surgery lymph node response disease-free survival overall survival |
| title | Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study |
| title_full | Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study |
| title_fullStr | Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study |
| title_full_unstemmed | Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study |
| title_short | Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study |
| title_sort | neoadjuvant chemotherapy plus radical surgery in locally advanced cervical cancer retrospective single center study |
| topic | cervical cancer neoadjuvant chemotherapy radical surgery lymph node response disease-free survival overall survival |
| url | https://www.mdpi.com/2072-6694/15/21/5207 |
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