Recent advances in the characterization of essential genes and development of a database of essential genes
Abstract Over the past few decades, there has been a significant interest in the study of essential genes, which are crucial for the survival of an organism under specific environmental conditions and thus have practical applications in the fields of synthetic biology and medicine. An increasing amo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | iMeta |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/imt2.157 |
| _version_ | 1797301862070747136 |
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| author | Ya‐Ting Liang Hao Luo Yan Lin Feng Gao |
| author_facet | Ya‐Ting Liang Hao Luo Yan Lin Feng Gao |
| author_sort | Ya‐Ting Liang |
| collection | DOAJ |
| description | Abstract Over the past few decades, there has been a significant interest in the study of essential genes, which are crucial for the survival of an organism under specific environmental conditions and thus have practical applications in the fields of synthetic biology and medicine. An increasing amount of experimental data on essential genes has been obtained with the continuous development of technological methods. Meanwhile, various computational prediction methods, related databases and web servers have emerged accordingly. To facilitate the study of essential genes, we have established a database of essential genes (DEG), which has become popular with continuous updates to facilitate essential gene feature analysis and prediction, drug and vaccine development, as well as artificial genome design and construction. In this article, we summarized the studies of essential genes, overviewed the relevant databases, and discussed their practical applications. Furthermore, we provided an overview of the main applications of DEG and conducted comprehensive analyses based on its latest version. However, it should be noted that the essential gene is a dynamic concept instead of a binary one, which presents both opportunities and challenges for their future development. |
| first_indexed | 2024-03-07T23:28:33Z |
| format | Article |
| id | doaj.art-51c62d967c78433282fecd6ca1081081 |
| institution | Directory Open Access Journal |
| issn | 2770-596X |
| language | English |
| last_indexed | 2024-03-07T23:28:33Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj.art-51c62d967c78433282fecd6ca10810812024-02-21T00:51:23ZengWileyiMeta2770-596X2024-02-0131n/an/a10.1002/imt2.157Recent advances in the characterization of essential genes and development of a database of essential genesYa‐Ting Liang0Hao Luo1Yan Lin2Feng Gao3Department of Physics Tianjin University Tianjin ChinaDepartment of Physics Tianjin University Tianjin ChinaDepartment of Physics Tianjin University Tianjin ChinaDepartment of Physics Tianjin University Tianjin ChinaAbstract Over the past few decades, there has been a significant interest in the study of essential genes, which are crucial for the survival of an organism under specific environmental conditions and thus have practical applications in the fields of synthetic biology and medicine. An increasing amount of experimental data on essential genes has been obtained with the continuous development of technological methods. Meanwhile, various computational prediction methods, related databases and web servers have emerged accordingly. To facilitate the study of essential genes, we have established a database of essential genes (DEG), which has become popular with continuous updates to facilitate essential gene feature analysis and prediction, drug and vaccine development, as well as artificial genome design and construction. In this article, we summarized the studies of essential genes, overviewed the relevant databases, and discussed their practical applications. Furthermore, we provided an overview of the main applications of DEG and conducted comprehensive analyses based on its latest version. However, it should be noted that the essential gene is a dynamic concept instead of a binary one, which presents both opportunities and challenges for their future development.https://doi.org/10.1002/imt2.157database of essential genesdrug and vaccine designessential genegene essentiality predictiongenome design |
| spellingShingle | Ya‐Ting Liang Hao Luo Yan Lin Feng Gao Recent advances in the characterization of essential genes and development of a database of essential genes iMeta database of essential genes drug and vaccine design essential gene gene essentiality prediction genome design |
| title | Recent advances in the characterization of essential genes and development of a database of essential genes |
| title_full | Recent advances in the characterization of essential genes and development of a database of essential genes |
| title_fullStr | Recent advances in the characterization of essential genes and development of a database of essential genes |
| title_full_unstemmed | Recent advances in the characterization of essential genes and development of a database of essential genes |
| title_short | Recent advances in the characterization of essential genes and development of a database of essential genes |
| title_sort | recent advances in the characterization of essential genes and development of a database of essential genes |
| topic | database of essential genes drug and vaccine design essential gene gene essentiality prediction genome design |
| url | https://doi.org/10.1002/imt2.157 |
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