Models for Translational Proton Radiobiology—From Bench to Bedside and Back
The number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call for basic and translational preclinical research. Open issues are the on-going discussion o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/16/4216 |
| _version_ | 1797524373217738752 |
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| author | Theresa Suckert Sindi Nexhipi Antje Dietrich Robin Koch Leoni A. Kunz-Schughart Emanuel Bahn Elke Beyreuther |
| author_facet | Theresa Suckert Sindi Nexhipi Antje Dietrich Robin Koch Leoni A. Kunz-Schughart Emanuel Bahn Elke Beyreuther |
| author_sort | Theresa Suckert |
| collection | DOAJ |
| description | The number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call for basic and translational preclinical research. Open issues are the on-going discussion on an energy-dependent varying proton RBE (relative biological effectiveness), a better characterization of normal tissue side effects and combination treatments with drugs originally developed for photon therapy. At the same time, novel possibilities arise, such as radioimmunotherapy, and new proton therapy schemata, such as FLASH irradiation and proton mini-beams. The study of those aspects demands for radiobiological models at different stages along the translational chain, allowing the investigation of mechanisms from the molecular level to whole organisms. Focusing on the challenges and specifics of proton research, this review summarizes the different available models, ranging from in vitro systems to animal studies of increasing complexity as well as complementing in silico approaches. |
| first_indexed | 2024-03-10T08:56:26Z |
| format | Article |
| id | doaj.art-51c7346b0c164ca5ac38435f5dd92f22 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T08:56:26Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-51c7346b0c164ca5ac38435f5dd92f222023-11-22T07:05:32ZengMDPI AGCancers2072-66942021-08-011316421610.3390/cancers13164216Models for Translational Proton Radiobiology—From Bench to Bedside and BackTheresa Suckert0Sindi Nexhipi1Antje Dietrich2Robin Koch3Leoni A. Kunz-Schughart4Emanuel Bahn5Elke Beyreuther6OncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, GermanyHeidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, GermanyHeidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01309 Dresden, GermanyThe number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call for basic and translational preclinical research. Open issues are the on-going discussion on an energy-dependent varying proton RBE (relative biological effectiveness), a better characterization of normal tissue side effects and combination treatments with drugs originally developed for photon therapy. At the same time, novel possibilities arise, such as radioimmunotherapy, and new proton therapy schemata, such as FLASH irradiation and proton mini-beams. The study of those aspects demands for radiobiological models at different stages along the translational chain, allowing the investigation of mechanisms from the molecular level to whole organisms. Focusing on the challenges and specifics of proton research, this review summarizes the different available models, ranging from in vitro systems to animal studies of increasing complexity as well as complementing in silico approaches.https://www.mdpi.com/2072-6694/13/16/4216proton therapyproton RBEtoxicitypreclinical modelscell cultureorganoids |
| spellingShingle | Theresa Suckert Sindi Nexhipi Antje Dietrich Robin Koch Leoni A. Kunz-Schughart Emanuel Bahn Elke Beyreuther Models for Translational Proton Radiobiology—From Bench to Bedside and Back Cancers proton therapy proton RBE toxicity preclinical models cell culture organoids |
| title | Models for Translational Proton Radiobiology—From Bench to Bedside and Back |
| title_full | Models for Translational Proton Radiobiology—From Bench to Bedside and Back |
| title_fullStr | Models for Translational Proton Radiobiology—From Bench to Bedside and Back |
| title_full_unstemmed | Models for Translational Proton Radiobiology—From Bench to Bedside and Back |
| title_short | Models for Translational Proton Radiobiology—From Bench to Bedside and Back |
| title_sort | models for translational proton radiobiology from bench to bedside and back |
| topic | proton therapy proton RBE toxicity preclinical models cell culture organoids |
| url | https://www.mdpi.com/2072-6694/13/16/4216 |
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