Basophils in pruritic skin diseases
Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In the skin, basophils are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213138/full |
| _version_ | 1797789207980146688 |
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| author | Daniela Wiebe Maren M. Limberg Natalie Gray Natalie Gray Ulrike Raap Ulrike Raap Ulrike Raap |
| author_facet | Daniela Wiebe Maren M. Limberg Natalie Gray Natalie Gray Ulrike Raap Ulrike Raap Ulrike Raap |
| author_sort | Daniela Wiebe |
| collection | DOAJ |
| description | Basophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In the skin, basophils are important players of the inflammatory immune response, as they release Th2 cytokines, including interleukin (IL)-4 and IL-13, subsequently inducing the early activation of T-cells. Further, basophils release a multitude of mediators, such as histamine and IL-31, which both play an important role in the initiation of the pruritic response via activation of sensory nerves. Chronic pruritus significantly affects the quality of life and the working capability of patients, though its mechanisms are not fully elucidated yet. Since basophils and neurons share many receptors and channels, bidirectional interaction mechanisms, which drive the sensation of itch, are highlighted in this review. |
| first_indexed | 2024-03-13T01:47:27Z |
| format | Article |
| id | doaj.art-51c7398c8373498bb14a6fd98ee5f38a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T01:47:27Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-51c7398c8373498bb14a6fd98ee5f38a2023-07-03T05:20:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12131381213138Basophils in pruritic skin diseasesDaniela Wiebe0Maren M. Limberg1Natalie Gray2Natalie Gray3Ulrike Raap4Ulrike Raap5Ulrike Raap6Division of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, GermanyDivision of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, GermanyDivision of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, GermanyDivision of Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, GermanyDivision of Experimental Allergy and Immunodermatology, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, GermanyResearch Center for Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, GermanyUniversity Clinic of Dermatology and Allergy, University of Oldenburg, Oldenburg, GermanyBasophils are rare cells in the peripheral blood which have the capability to infiltrate into the skin. Invasion of basophils has been detected in pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In the skin, basophils are important players of the inflammatory immune response, as they release Th2 cytokines, including interleukin (IL)-4 and IL-13, subsequently inducing the early activation of T-cells. Further, basophils release a multitude of mediators, such as histamine and IL-31, which both play an important role in the initiation of the pruritic response via activation of sensory nerves. Chronic pruritus significantly affects the quality of life and the working capability of patients, though its mechanisms are not fully elucidated yet. Since basophils and neurons share many receptors and channels, bidirectional interaction mechanisms, which drive the sensation of itch, are highlighted in this review.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213138/fullbasophilsIL-31atopic dermatitisneuro-immune interactionpruritus |
| spellingShingle | Daniela Wiebe Maren M. Limberg Natalie Gray Natalie Gray Ulrike Raap Ulrike Raap Ulrike Raap Basophils in pruritic skin diseases Frontiers in Immunology basophils IL-31 atopic dermatitis neuro-immune interaction pruritus |
| title | Basophils in pruritic skin diseases |
| title_full | Basophils in pruritic skin diseases |
| title_fullStr | Basophils in pruritic skin diseases |
| title_full_unstemmed | Basophils in pruritic skin diseases |
| title_short | Basophils in pruritic skin diseases |
| title_sort | basophils in pruritic skin diseases |
| topic | basophils IL-31 atopic dermatitis neuro-immune interaction pruritus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1213138/full |
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