MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis
Abstract Objective To investigate the diagnostic performance of microRNA‐21 detected in serum or sputum as a biomarker for lung carcinoma identification through pooling the open published data. Methods Clinical diagnostic studies related to microRNA‐21 as a biomarker for lung carcinoma identificatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14242 |
| _version_ | 1798017100540805120 |
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| author | Haiyan Wang Jia Xu Ling Ding |
| author_facet | Haiyan Wang Jia Xu Ling Ding |
| author_sort | Haiyan Wang |
| collection | DOAJ |
| description | Abstract Objective To investigate the diagnostic performance of microRNA‐21 detected in serum or sputum as a biomarker for lung carcinoma identification through pooling the open published data. Methods Clinical diagnostic studies related to microRNA‐21 as a biomarker for lung carcinoma identification were electronically searched in the databases of Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Google Scholar. The data of the included studies was extracted and made pooling of diagnostic sensitivity, specificity, diagnostic odds ratio (DOR), area under the summary receiver operating characteristic curve (ROC) (AUC) for microRNA‐21 expression in serum or sputum as a biomarker for lung carcinoma identification. The publication bias was evaluated by Deek's funnel plot. Results Seventeen diagnostic studies were finally included and made data pooling. For the included 17 studies, 4 investigated the microRNA‐21 expression in sputum and 13 studies in serum. The pooled diagnostic sensitivity and specificity were 0.73 (95% CI, 0.67–0.78) and 0.81 (95% CI, 0.75–0.85), respectively, under random effect model. The combined DOR was 9.65 (95% CI, 6.64–14.03) with the AUC of 0.84 (95% CI, 0.80–0.87). Given a pre‐test probability of 50%, the post‐test positive probability and post‐test negative probability were 79% and 25%, respectively, by using microRNA‐21 as a biomarker for lung carcinoma diagnosis. Deek's funnel was obviously asymmetry and indicated significant publication bias (p < 0.05). Conclusion MicroRNA‐21 in serum or sputum was a promising biomarker for lung cancer identification with relative high diagnostic sensitivity and specificity. |
| first_indexed | 2024-04-11T16:01:18Z |
| format | Article |
| id | doaj.art-51c78b8be1ba4651b8d1ecdf0cad969b |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T16:01:18Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-51c78b8be1ba4651b8d1ecdf0cad969b2022-12-22T04:14:58ZengWileyThoracic Cancer1759-77061759-77142022-02-0113331632110.1111/1759-7714.14242MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysisHaiyan Wang0Jia Xu1Ling Ding2Department of Respiratory Hangzhou Third People's Hospital Hangzhou ChinaDepartment of Respiratory Hangzhou Third People's Hospital Hangzhou ChinaDepartment of Respiratory Hangzhou Third People's Hospital Hangzhou ChinaAbstract Objective To investigate the diagnostic performance of microRNA‐21 detected in serum or sputum as a biomarker for lung carcinoma identification through pooling the open published data. Methods Clinical diagnostic studies related to microRNA‐21 as a biomarker for lung carcinoma identification were electronically searched in the databases of Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Google Scholar. The data of the included studies was extracted and made pooling of diagnostic sensitivity, specificity, diagnostic odds ratio (DOR), area under the summary receiver operating characteristic curve (ROC) (AUC) for microRNA‐21 expression in serum or sputum as a biomarker for lung carcinoma identification. The publication bias was evaluated by Deek's funnel plot. Results Seventeen diagnostic studies were finally included and made data pooling. For the included 17 studies, 4 investigated the microRNA‐21 expression in sputum and 13 studies in serum. The pooled diagnostic sensitivity and specificity were 0.73 (95% CI, 0.67–0.78) and 0.81 (95% CI, 0.75–0.85), respectively, under random effect model. The combined DOR was 9.65 (95% CI, 6.64–14.03) with the AUC of 0.84 (95% CI, 0.80–0.87). Given a pre‐test probability of 50%, the post‐test positive probability and post‐test negative probability were 79% and 25%, respectively, by using microRNA‐21 as a biomarker for lung carcinoma diagnosis. Deek's funnel was obviously asymmetry and indicated significant publication bias (p < 0.05). Conclusion MicroRNA‐21 in serum or sputum was a promising biomarker for lung cancer identification with relative high diagnostic sensitivity and specificity.https://doi.org/10.1111/1759-7714.14242biomarkerdiagnosislung carcinomameta‐analysismicroRNA‐21 |
| spellingShingle | Haiyan Wang Jia Xu Ling Ding MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis Thoracic Cancer biomarker diagnosis lung carcinoma meta‐analysis microRNA‐21 |
| title | MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis |
| title_full | MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis |
| title_fullStr | MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis |
| title_full_unstemmed | MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis |
| title_short | MicroRNA‐21 was a promising biomarker for lung carcinoma diagnosis: An update meta‐analysis |
| title_sort | microrna 21 was a promising biomarker for lung carcinoma diagnosis an update meta analysis |
| topic | biomarker diagnosis lung carcinoma meta‐analysis microRNA‐21 |
| url | https://doi.org/10.1111/1759-7714.14242 |
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