A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers
Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing p...
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2013-01-01
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| Series: | Science and Technology of Advanced Materials |
| Online Access: | http://dx.doi.org/10.1088/1468-6996/14/5/054402 |
| _version_ | 1818379892002127872 |
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| author | Chen Zhao, Martin M Thuo and Xinyu Liu |
| author_facet | Chen Zhao, Martin M Thuo and Xinyu Liu |
| author_sort | Chen Zhao, Martin M Thuo and Xinyu Liu |
| collection | DOAJ |
| description | Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and its electrochemical reader will enable the acquisition of high-density, statistically meaningful diagnostic information at the point of care in a rapid and cost-efficient way. |
| first_indexed | 2024-12-14T02:10:00Z |
| format | Article |
| id | doaj.art-51c805b2d3084262b95f624be17e5003 |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-12-14T02:10:00Z |
| publishDate | 2013-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-51c805b2d3084262b95f624be17e50032022-12-21T23:20:47ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142013-01-0114505440210.1088/1468-6996/14/5/054402A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkersChen Zhao, Martin M Thuo and Xinyu LiuPaper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and its electrochemical reader will enable the acquisition of high-density, statistically meaningful diagnostic information at the point of care in a rapid and cost-efficient way.http://dx.doi.org/10.1088/1468-6996/14/5/054402 |
| spellingShingle | Chen Zhao, Martin M Thuo and Xinyu Liu A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers Science and Technology of Advanced Materials |
| title | A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers |
| title_full | A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers |
| title_fullStr | A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers |
| title_full_unstemmed | A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers |
| title_short | A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers |
| title_sort | microfluidic paper based electrochemical biosensor array for multiplexed detection of metabolic biomarkers |
| url | http://dx.doi.org/10.1088/1468-6996/14/5/054402 |
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