Development of an Aged Full-Thickness Skin Model Using Flexible Skin-on-a-Chip Subjected to Mechanical Stimulus Reflecting the Circadian Rhythm

Development of an Aged Full-Thickness Skin Model Using Flexible Skin-on-a-Chip Subjected to Mechanical Stimulus Reflecting the Circadian Rhythm

The skin is subject to both intrinsic aging caused by metabolic processes in the body and extrinsic aging caused by exposure to environmental factors. Intrinsic aging is an important obstacle to in vitro experimentation as its long-term progression is difficult to replicate. Here, we accelerated agi...

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Bibliographic Details
Main Authors: Subin Jeong, Jisue Kim, Hye Mi Jeon, Kyunghee Kim, Gun Yong Sung
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
flexible skin-on-a-chip
circadian rhythm
periodic compressive stress
Online Access:https://www.mdpi.com/1422-0067/22/23/12788

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