Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center
Given the importance of identifying prodromes of dementia with specific etiologies, we assessed whether seven latent classes of mild cognitive impairment (MCI), defined empirically based on cognitive, functional, and neuropsychiatric information at initial visit, are associated with distinct clinica...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-09-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996118301633 |
| _version_ | 1829492169944072192 |
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| author | John J. Hanfelt Limin Peng Felicia C. Goldstein James J. Lah |
| author_facet | John J. Hanfelt Limin Peng Felicia C. Goldstein James J. Lah |
| author_sort | John J. Hanfelt |
| collection | DOAJ |
| description | Given the importance of identifying prodromes of dementia with specific etiologies, we assessed whether seven latent classes of mild cognitive impairment (MCI), defined empirically based on cognitive, functional, and neuropsychiatric information at initial visit, are associated with distinct clinical outcomes and neuropathological features. We separated 6034 participants with a baseline diagnosis of MCI into seven latent classes using previously defined criteria. We found that these latent classes of MCI differed significantly in their clinical outcomes, survival time, and neuropathology. Two amnestic multi-domain subgroups, as well as two other subgroups with functional impairments and neuropsychiatric disturbances, were at higher risk of not only a ‘pure’ form of Alzheimer's disease (AD) pathology, but also a ‘mixed’ pathology consisting of both AD and vascular features. Moreover, the seven latent classes had different risks of Lewy bodies, hippocampal sclerosis, and frontotemporal lobar degeneration (FTLD). This study indicates that data-driven subgroups of MCI are clinicopathologically informative and, with refinement, could lead to targeted interventions focused on each etiology. |
| first_indexed | 2024-12-16T06:09:57Z |
| format | Article |
| id | doaj.art-51cc297d3ac946d5ab3d43b56246d2d4 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T06:09:57Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-51cc297d3ac946d5ab3d43b56246d2d42022-12-21T22:41:25ZengElsevierNeurobiology of Disease1095-953X2018-09-011176271Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating CenterJohn J. Hanfelt0Limin Peng1Felicia C. Goldstein2James J. Lah3Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, United States; Emory Alzheimer's Disease Research Center, United States; Correspondence to: J. J. Hanfelt, Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, 1518 Clifton Road, N.E., Atlanta, GA 30322, United States.Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, United StatesDepartment of Neurology, Emory University School of Medicine, United States; Emory Alzheimer's Disease Research Center, United StatesDepartment of Neurology, Emory University School of Medicine, United States; Emory Alzheimer's Disease Research Center, United States; Correspondence to: J. J. Lah, Department of Neurology, Emory University School of Medicine, 12 Executive Park Dr., N.E., Atlanta, GA 30329, United States.Given the importance of identifying prodromes of dementia with specific etiologies, we assessed whether seven latent classes of mild cognitive impairment (MCI), defined empirically based on cognitive, functional, and neuropsychiatric information at initial visit, are associated with distinct clinical outcomes and neuropathological features. We separated 6034 participants with a baseline diagnosis of MCI into seven latent classes using previously defined criteria. We found that these latent classes of MCI differed significantly in their clinical outcomes, survival time, and neuropathology. Two amnestic multi-domain subgroups, as well as two other subgroups with functional impairments and neuropsychiatric disturbances, were at higher risk of not only a ‘pure’ form of Alzheimer's disease (AD) pathology, but also a ‘mixed’ pathology consisting of both AD and vascular features. Moreover, the seven latent classes had different risks of Lewy bodies, hippocampal sclerosis, and frontotemporal lobar degeneration (FTLD). This study indicates that data-driven subgroups of MCI are clinicopathologically informative and, with refinement, could lead to targeted interventions focused on each etiology.http://www.sciencedirect.com/science/article/pii/S0969996118301633Alzheimer's diseaseCompeting risksFrontotemporal lobar degenerationLatent class analysisLewy bodiesMild cognitive impairment |
| spellingShingle | John J. Hanfelt Limin Peng Felicia C. Goldstein James J. Lah Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center Neurobiology of Disease Alzheimer's disease Competing risks Frontotemporal lobar degeneration Latent class analysis Lewy bodies Mild cognitive impairment |
| title | Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center |
| title_full | Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center |
| title_fullStr | Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center |
| title_full_unstemmed | Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center |
| title_short | Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center |
| title_sort | latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology analysis of data from the national alzheimer s coordinating center |
| topic | Alzheimer's disease Competing risks Frontotemporal lobar degeneration Latent class analysis Lewy bodies Mild cognitive impairment |
| url | http://www.sciencedirect.com/science/article/pii/S0969996118301633 |
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