Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance
Abstract Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for patients with osteosarcoma have stagnated over the past four decades Multiple-drug resistance—the capacity of cancer cells to become simultaneo...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01309-x |
| _version_ | 1797577296240967680 |
|---|---|
| author | Shuang Qin Yuting Wang Chunhui Ma Qi Lv |
| author_facet | Shuang Qin Yuting Wang Chunhui Ma Qi Lv |
| author_sort | Shuang Qin |
| collection | DOAJ |
| description | Abstract Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for patients with osteosarcoma have stagnated over the past four decades Multiple-drug resistance—the capacity of cancer cells to become simultaneously resistant to multiple drugs—remains a significant obstacle to effective chemotherapy. The recent studies have shown that noncoding RNAs can regulate the expression of target genes. It has been proposed that “competing endogenous RNA” activity forms a large-scale regulatory network across the transcriptome, playing important roles in pathological conditions such as cancer. Numerous studies have highlighted that circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competitive endogenous RNAs, thereby affecting and regulating the expression of mRNAs and target genes. These circRNA/lncRNA-associated competitive endogenous RNAs are hypothesized to play significant roles in cancer initiation and progression. Noncoding RNAs (ncRNAs) play an important role in tumor resistance to chemotherapy. However, the molecular mechanisms of the lncRNA/circRNA-miRNA-mRNA competitive endogenous RNA network in drug resistance of osteosarcoma remain unclear. An in-depth study of the molecular mechanisms of drug resistance in osteosarcoma and the elucidation of effective intervention targets are of great significance for improving the overall recovery of patients with osteosarcoma. This review focuses on the molecular mechanisms underlying chemotherapy resistance in osteosarcoma in circRNA-, lncRNA-, and miRNA-mediated competitive endogenous networks. |
| first_indexed | 2024-03-10T22:06:15Z |
| format | Article |
| id | doaj.art-51ccf9eaab7346b696cf11f0b4c8933a |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-10T22:06:15Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-51ccf9eaab7346b696cf11f0b4c8933a2023-11-19T12:46:48ZengBMCEuropean Journal of Medical Research2047-783X2023-09-012811910.1186/s40001-023-01309-xCompetitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistanceShuang Qin0Yuting Wang1Chunhui Ma2Qi Lv3Department of Medical Imaging, Tongji Hospital, Tongji University School of MedicineDepartment of Medical Imaging, Tongji Hospital, Tongji University School of MedicineDepartment of Orthopedics, Shanghai General Hospital of Shanghai Jiaotong UniversityDepartment of Medical Imaging, Tongji Hospital, Tongji University School of MedicineAbstract Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for patients with osteosarcoma have stagnated over the past four decades Multiple-drug resistance—the capacity of cancer cells to become simultaneously resistant to multiple drugs—remains a significant obstacle to effective chemotherapy. The recent studies have shown that noncoding RNAs can regulate the expression of target genes. It has been proposed that “competing endogenous RNA” activity forms a large-scale regulatory network across the transcriptome, playing important roles in pathological conditions such as cancer. Numerous studies have highlighted that circular RNAs (circRNAs) and long noncoding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competitive endogenous RNAs, thereby affecting and regulating the expression of mRNAs and target genes. These circRNA/lncRNA-associated competitive endogenous RNAs are hypothesized to play significant roles in cancer initiation and progression. Noncoding RNAs (ncRNAs) play an important role in tumor resistance to chemotherapy. However, the molecular mechanisms of the lncRNA/circRNA-miRNA-mRNA competitive endogenous RNA network in drug resistance of osteosarcoma remain unclear. An in-depth study of the molecular mechanisms of drug resistance in osteosarcoma and the elucidation of effective intervention targets are of great significance for improving the overall recovery of patients with osteosarcoma. This review focuses on the molecular mechanisms underlying chemotherapy resistance in osteosarcoma in circRNA-, lncRNA-, and miRNA-mediated competitive endogenous networks.https://doi.org/10.1186/s40001-023-01309-xOsteosarcomaCircRNALncRNAmiRNACompetitive endogenous RNAChemotherapy resistance |
| spellingShingle | Shuang Qin Yuting Wang Chunhui Ma Qi Lv Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance European Journal of Medical Research Osteosarcoma CircRNA LncRNA miRNA Competitive endogenous RNA Chemotherapy resistance |
| title | Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance |
| title_full | Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance |
| title_fullStr | Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance |
| title_full_unstemmed | Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance |
| title_short | Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance |
| title_sort | competitive endogenous network of circrna lncrna and mirna in osteosarcoma chemoresistance |
| topic | Osteosarcoma CircRNA LncRNA miRNA Competitive endogenous RNA Chemotherapy resistance |
| url | https://doi.org/10.1186/s40001-023-01309-x |
| work_keys_str_mv | AT shuangqin competitiveendogenousnetworkofcircrnalncrnaandmirnainosteosarcomachemoresistance AT yutingwang competitiveendogenousnetworkofcircrnalncrnaandmirnainosteosarcomachemoresistance AT chunhuima competitiveendogenousnetworkofcircrnalncrnaandmirnainosteosarcomachemoresistance AT qilv competitiveendogenousnetworkofcircrnalncrnaandmirnainosteosarcomachemoresistance |