A positive mechanobiological feedback loop controls bistable switching of cardiac fibroblast phenotype
Abstract Cardiac fibrosis is associated with activation of cardiac fibroblasts (CFs), a pathological, phenotypic transition that is widely believed to be irreversible in the late stages of disease development. Sensing of a stiffened mechanical environment through regulation of integrin-based adhesio...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
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| Series: | Cell Discovery |
| Online Access: | https://doi.org/10.1038/s41421-022-00427-w |