Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis
Abstract Background To compare the safety and efficacy between endoscopic sinus surgery and different biologics in treating chronic rhinosinusitis with nasal polyps in adults by reviewing the existing clinical trials. Methods Data extraction and risk of bias assessment were conducted by 2 independen...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Clinical and Translational Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/clt2.12269 |
| _version_ | 1797794557303193600 |
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| author | Jiani Chen Huan Wang Chen Zhang Le Shi Qianqian Zhang Xiaole Song Dehui Wang Li Hu Hongmeng Yu Xicai Sun |
| author_facet | Jiani Chen Huan Wang Chen Zhang Le Shi Qianqian Zhang Xiaole Song Dehui Wang Li Hu Hongmeng Yu Xicai Sun |
| author_sort | Jiani Chen |
| collection | DOAJ |
| description | Abstract Background To compare the safety and efficacy between endoscopic sinus surgery and different biologics in treating chronic rhinosinusitis with nasal polyps in adults by reviewing the existing clinical trials. Methods Data extraction and risk of bias assessment were conducted by 2 independent reviewers according to the PRISMA recommendations and any disagreement was resolved by a third investigator. Outcomes were measured through a random‐effects model. We searched Embase, Web of Science, MEDLINE, Cochrane, and other relevant sources from its inception to April 30, 2022. We included randomized controlled trials(RCTs) involving endoscopic sinus surgery (ESS) or biologics in treating adult patients with chronic rhinosinusitis with nasal polyps. Studies involving other miscellaneous diseases, non‐RCT design, and insufficient participants or follow‐up were excluded. Results In this systematic review, five RCTs and 1748 patients were included. All the biologics, as well as ESS, could significantly improve key nasal outcomes in CRSwNP both at 6 months and 1 year. Dupilumab exhibited better efficacy than ESS in improving SNOT‐22 scores at one year. However, ESS showed superiority over three biologics in improving nasal congestion scores (NCS) at two various time points, except for better efficacy of Dupilumab at 1 year. For the loss of smell scores, a greater improvement was observed in the Dupilumab cohort compared with other biologics and even ESS counterparts. Safety analysis showed no significant difference between the ESS cohort and biologic treatment. Conclusions In summary, ESS showed comparable improvement in quality of life and symptoms to Omalizumab, Mepolizumab, and Benralizumab. Dupilumab seems to be more effective than ESS in selected items, whereas head‐to‐head trials and real‐world studies are urgent to compare their efficacy. Our findings also showed that biologics could be applied as alternative or adjuvant therapy for uncontrolled severe CRSwNP. |
| first_indexed | 2024-03-13T03:03:33Z |
| format | Article |
| id | doaj.art-51cdec963844491fb2099dee04a93e42 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-03-13T03:03:33Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-51cdec963844491fb2099dee04a93e422023-06-27T08:16:39ZengWileyClinical and Translational Allergy2045-70222023-06-01136n/an/a10.1002/clt2.12269Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysisJiani Chen0Huan Wang1Chen Zhang2Le Shi3Qianqian Zhang4Xiaole Song5Dehui Wang6Li Hu7Hongmeng Yu8Xicai Sun9ENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital Fudan University Shanghai ChinaAbstract Background To compare the safety and efficacy between endoscopic sinus surgery and different biologics in treating chronic rhinosinusitis with nasal polyps in adults by reviewing the existing clinical trials. Methods Data extraction and risk of bias assessment were conducted by 2 independent reviewers according to the PRISMA recommendations and any disagreement was resolved by a third investigator. Outcomes were measured through a random‐effects model. We searched Embase, Web of Science, MEDLINE, Cochrane, and other relevant sources from its inception to April 30, 2022. We included randomized controlled trials(RCTs) involving endoscopic sinus surgery (ESS) or biologics in treating adult patients with chronic rhinosinusitis with nasal polyps. Studies involving other miscellaneous diseases, non‐RCT design, and insufficient participants or follow‐up were excluded. Results In this systematic review, five RCTs and 1748 patients were included. All the biologics, as well as ESS, could significantly improve key nasal outcomes in CRSwNP both at 6 months and 1 year. Dupilumab exhibited better efficacy than ESS in improving SNOT‐22 scores at one year. However, ESS showed superiority over three biologics in improving nasal congestion scores (NCS) at two various time points, except for better efficacy of Dupilumab at 1 year. For the loss of smell scores, a greater improvement was observed in the Dupilumab cohort compared with other biologics and even ESS counterparts. Safety analysis showed no significant difference between the ESS cohort and biologic treatment. Conclusions In summary, ESS showed comparable improvement in quality of life and symptoms to Omalizumab, Mepolizumab, and Benralizumab. Dupilumab seems to be more effective than ESS in selected items, whereas head‐to‐head trials and real‐world studies are urgent to compare their efficacy. Our findings also showed that biologics could be applied as alternative or adjuvant therapy for uncontrolled severe CRSwNP.https://doi.org/10.1002/clt2.12269biologicschronic rhinosinusitis with nasal polypsendoscopic sinus surgeryquality of lifesystematic review |
| spellingShingle | Jiani Chen Huan Wang Chen Zhang Le Shi Qianqian Zhang Xiaole Song Dehui Wang Li Hu Hongmeng Yu Xicai Sun Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis Clinical and Translational Allergy biologics chronic rhinosinusitis with nasal polyps endoscopic sinus surgery quality of life systematic review |
| title | Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis |
| title_full | Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis |
| title_fullStr | Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis |
| title_full_unstemmed | Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis |
| title_short | Comparative short‐term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps: A network meta‐analysis |
| title_sort | comparative short term efficacy of endoscopic sinus surgery and biological therapies in chronic rhinosinusitis with nasal polyps a network meta analysis |
| topic | biologics chronic rhinosinusitis with nasal polyps endoscopic sinus surgery quality of life systematic review |
| url | https://doi.org/10.1002/clt2.12269 |
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