Plasma plant sterols serve as poor markers of cholesterol absorption in man[S]
The validation of the use of plasma plant sterols as a marker of cholesterol absorption is frail. Nevertheless, plant sterol concentrations are routinely used to describe treatment-induced changes in cholesterol absorption. Their use has also been advocated as a clinical tool to tailor cholesterol-l...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-04-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520422175 |
| _version_ | 1818920471250337792 |
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| author | Lily Jakulj Hussein Mohammed Theo H. van Dijk Theo Boer Scott Turner Albert K. Groen Maud N. Vissers Erik S.G. Stroes |
| author_facet | Lily Jakulj Hussein Mohammed Theo H. van Dijk Theo Boer Scott Turner Albert K. Groen Maud N. Vissers Erik S.G. Stroes |
| author_sort | Lily Jakulj |
| collection | DOAJ |
| description | The validation of the use of plasma plant sterols as a marker of cholesterol absorption is frail. Nevertheless, plant sterol concentrations are routinely used to describe treatment-induced changes in cholesterol absorption. Their use has also been advocated as a clinical tool to tailor cholesterol-lowering therapy. Prior to wider implementation, however, the validity of plant sterols as absorption markers needs solid evaluation. Therefore, we compared plasma plant sterol concentrations to gold-standard stable isotope-determined cholesterol absorption. Plasma campesterol/TC concentrations (camp/TC) were measured in a population of 175 mildly hypercholesterolemic individuals (age: 59.7 ± 5.6 years; BMI: 25.5 ± 2.9kg/m2; LDL-C: 4.01 ± 0.56 mmol/l). We compared cholesterol absorption according to the plasma dual-isotope method in subjects with the highest camp/TC concentrations (N = 41, camp/TC: 2.14 ± 0.68 μg/mg) and the lowest camp/TC concentrations (N = 39, camp/TC: 0.97 ± 0.22 μg/mg). Fractional cholesterol absorption did not differ between the groups (24 ± 12% versus 25 ± 16%, P = 0.60), nor was it associated with plasma camp/TC concentrations in the total population of 80 individuals (β= 0.13; P = 0.30, adjusted for BMI and plasma triglycerides). Our findings do not support a relation between plasma plant sterol concentrations and true cholesterol absorption and, therefore, do not favor the use of these sterols as markers of cholesterol absorption. This bears direct consequences for the interpretation of earlier studies, as well as for future studies targeting intestinal regulation of cholesterol metabolism. |
| first_indexed | 2024-12-20T01:22:16Z |
| format | Article |
| id | doaj.art-51cdfd9b3059455baccb98034622d999 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-20T01:22:16Z |
| publishDate | 2013-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-51cdfd9b3059455baccb98034622d9992022-12-21T19:58:23ZengElsevierJournal of Lipid Research0022-22752013-04-0154411441150Plasma plant sterols serve as poor markers of cholesterol absorption in man[S]Lily Jakulj0Hussein Mohammed1Theo H. van Dijk2Theo Boer3Scott Turner4Albert K. Groen5Maud N. Vissers6Erik S.G. Stroes7To whom correspondence should be addressed l.jakulj@amc.nl; Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands; To whom correspondence should be addressed l.jakulj@amc.nlKinemed Inc., Emeryville, CA; andDepartments of Pediatrics and Laboratory Medicine, Groningen, The Netherlands; University Medical Center Groningen, Groningen, The NetherlandsUniversity Medical Center Groningen, Groningen, The NetherlandsKinemed Inc., Emeryville, CA; andDepartments of Pediatrics and Laboratory Medicine, Groningen, The Netherlands; University Medical Center Groningen, Groningen, The NetherlandsDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Vascular Medicine, Academic Medical Center, Amsterdam, The NetherlandsThe validation of the use of plasma plant sterols as a marker of cholesterol absorption is frail. Nevertheless, plant sterol concentrations are routinely used to describe treatment-induced changes in cholesterol absorption. Their use has also been advocated as a clinical tool to tailor cholesterol-lowering therapy. Prior to wider implementation, however, the validity of plant sterols as absorption markers needs solid evaluation. Therefore, we compared plasma plant sterol concentrations to gold-standard stable isotope-determined cholesterol absorption. Plasma campesterol/TC concentrations (camp/TC) were measured in a population of 175 mildly hypercholesterolemic individuals (age: 59.7 ± 5.6 years; BMI: 25.5 ± 2.9kg/m2; LDL-C: 4.01 ± 0.56 mmol/l). We compared cholesterol absorption according to the plasma dual-isotope method in subjects with the highest camp/TC concentrations (N = 41, camp/TC: 2.14 ± 0.68 μg/mg) and the lowest camp/TC concentrations (N = 39, camp/TC: 0.97 ± 0.22 μg/mg). Fractional cholesterol absorption did not differ between the groups (24 ± 12% versus 25 ± 16%, P = 0.60), nor was it associated with plasma camp/TC concentrations in the total population of 80 individuals (β= 0.13; P = 0.30, adjusted for BMI and plasma triglycerides). Our findings do not support a relation between plasma plant sterol concentrations and true cholesterol absorption and, therefore, do not favor the use of these sterols as markers of cholesterol absorption. This bears direct consequences for the interpretation of earlier studies, as well as for future studies targeting intestinal regulation of cholesterol metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520422175campesterolstable isotopesintestinephytosterols |
| spellingShingle | Lily Jakulj Hussein Mohammed Theo H. van Dijk Theo Boer Scott Turner Albert K. Groen Maud N. Vissers Erik S.G. Stroes Plasma plant sterols serve as poor markers of cholesterol absorption in man[S] Journal of Lipid Research campesterol stable isotopes intestine phytosterols |
| title | Plasma plant sterols serve as poor markers of cholesterol absorption in man[S] |
| title_full | Plasma plant sterols serve as poor markers of cholesterol absorption in man[S] |
| title_fullStr | Plasma plant sterols serve as poor markers of cholesterol absorption in man[S] |
| title_full_unstemmed | Plasma plant sterols serve as poor markers of cholesterol absorption in man[S] |
| title_short | Plasma plant sterols serve as poor markers of cholesterol absorption in man[S] |
| title_sort | plasma plant sterols serve as poor markers of cholesterol absorption in man s |
| topic | campesterol stable isotopes intestine phytosterols |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520422175 |
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