A3 Adenosine Receptors Modulate Hypoxia-inducible Factor-1a Expression in Human A375 Melanoma Cells

A3 Adenosine Receptors Modulate Hypoxia-inducible Factor-1a Expression in Human A375 Melanoma Cells

Hypoxia-inducible factor-1 (HIF-1) is a key regulator of genes crucial to many aspects of cancer biology. The purine nucleoside, adenosine, accumulates within many tissues under hypoxic conditions, including that of tumors. Because the levels of both HIF-1 and adenosine are elevated within the hypox...

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Bibliographic Details
Main Authors: Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Edward Leung, Stephen MacLennan, Pier Giovanni Baraldi, Pier Andrea Borea
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
adenosine
A3 receptors
HIF-1α
hypoxia
tumor cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605801137

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