High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner
Metabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation of sex- and hormone-dependent changes in body weight, blood pressure, blood lipids, oxidative stress markers, and alterations in different types of mem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/4/341 |
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| author | Edwin Chávez-Gutiérrez Claudia Erika Fuentes-Venado Lorena Rodríguez-Páez Christian Guerra-Araiza Carlos Larqué Erick Martínez-Herrera María Esther Ocharan-Hernández Joel Lomelí Marco A. Loza-Mejía Juan Rodrigo Salazar Dulce María Meneses-Ruiz Juan Manuel Gallardo Rodolfo Pinto-Almazán |
| author_facet | Edwin Chávez-Gutiérrez Claudia Erika Fuentes-Venado Lorena Rodríguez-Páez Christian Guerra-Araiza Carlos Larqué Erick Martínez-Herrera María Esther Ocharan-Hernández Joel Lomelí Marco A. Loza-Mejía Juan Rodrigo Salazar Dulce María Meneses-Ruiz Juan Manuel Gallardo Rodolfo Pinto-Almazán |
| author_sort | Edwin Chávez-Gutiérrez |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation of sex- and hormone-dependent changes in body weight, blood pressure, blood lipids, oxidative stress markers, and alterations in different types of memory in Sprague–Dawley rats fed with a high fat and high fructose (HFHF) diet were evaluated. After 12 weeks of feeding the male and female rats with HFHF, body weight gain, increase in blood pressure, and generation of dyslipidemia compared to the animals fed with chow diet were observed. Regarding memory, it was noted that gonadectomy reverted the effects of HFHF in the 24 h novel object recognition task and in spatial learning/memory analyzed through Morris water maze, males being more affected than females. Nevertheless, gonadectomy did not revert long-term memory impairment in the passive avoidance task induced by HFHF nor in male or female rats. On the other hand, sex-hormone–diet interaction was observed in the plasma concentration of malondialdehyde and nitric oxide. These results suggest that the changes observed in the memory and learning of MetS animals are sex- and hormone-dependent and correlate to an increase in oxidative stress. |
| first_indexed | 2024-03-09T13:19:21Z |
| format | Article |
| id | doaj.art-51ce6c82ddda425985f9ec8caed62487 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T13:19:21Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-51ce6c82ddda425985f9ec8caed624872023-11-30T21:32:14ZengMDPI AGMetabolites2218-19892022-04-0112434110.3390/metabo12040341High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent MannerEdwin Chávez-Gutiérrez0Claudia Erika Fuentes-Venado1Lorena Rodríguez-Páez2Christian Guerra-Araiza3Carlos Larqué4Erick Martínez-Herrera5María Esther Ocharan-Hernández6Joel Lomelí7Marco A. Loza-Mejía8Juan Rodrigo Salazar9Dulce María Meneses-Ruiz10Juan Manuel Gallardo11Rodolfo Pinto-Almazán12Doctorado en Ciencias en Biomedicina y Biotecnología Molecular, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, MexicoServicio de Medicina Física y Rehabilitación, Hospital General de Zona No 197, Texcoco 56108, MexicoDepartamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación Manuel Carpio y Plan de Ayala s/n, Col. Santo Tomás, Miguel Hidalgo, CP 11340, CDMX, Mexico City 11340, MexicoMedical Research Unit in Pharmacology, Specialities Hospital Bernardo Sepúlveda, National Medical Center XXI Century, Social Security Mexican Institute (IMSS), Av. Cuauhtémoc 330, Mexico City 06720, MexicoDepartamento de Embriología y Genética, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad # 3000, Col. Ciudad Universitaria, Alcaldía de Coyoacán, Mexico City 04510, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoDesign, Isolation, and Synthesis of Bioactive Molecules Research Group, Chemical Sciences School, Universidad La Salle-México, Benjamín Franklin 45, Mexico City 06140, MexicoDesign, Isolation, and Synthesis of Bioactive Molecules Research Group, Chemical Sciences School, Universidad La Salle-México, Benjamín Franklin 45, Mexico City 06140, MexicoNoncommunicable Diseases Research Group, Universidad La Salle-México, Benjamín Franklin 45, Mexico City 06140, MexicoUnidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoNoncommunicable Diseases Research Group, Universidad La Salle-México, Benjamín Franklin 45, Mexico City 06140, MexicoMetabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation of sex- and hormone-dependent changes in body weight, blood pressure, blood lipids, oxidative stress markers, and alterations in different types of memory in Sprague–Dawley rats fed with a high fat and high fructose (HFHF) diet were evaluated. After 12 weeks of feeding the male and female rats with HFHF, body weight gain, increase in blood pressure, and generation of dyslipidemia compared to the animals fed with chow diet were observed. Regarding memory, it was noted that gonadectomy reverted the effects of HFHF in the 24 h novel object recognition task and in spatial learning/memory analyzed through Morris water maze, males being more affected than females. Nevertheless, gonadectomy did not revert long-term memory impairment in the passive avoidance task induced by HFHF nor in male or female rats. On the other hand, sex-hormone–diet interaction was observed in the plasma concentration of malondialdehyde and nitric oxide. These results suggest that the changes observed in the memory and learning of MetS animals are sex- and hormone-dependent and correlate to an increase in oxidative stress.https://www.mdpi.com/2218-1989/12/4/341metabolic syndromeovariectomyorchiectomymemoryoxidative stress |
| spellingShingle | Edwin Chávez-Gutiérrez Claudia Erika Fuentes-Venado Lorena Rodríguez-Páez Christian Guerra-Araiza Carlos Larqué Erick Martínez-Herrera María Esther Ocharan-Hernández Joel Lomelí Marco A. Loza-Mejía Juan Rodrigo Salazar Dulce María Meneses-Ruiz Juan Manuel Gallardo Rodolfo Pinto-Almazán High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner Metabolites metabolic syndrome ovariectomy orchiectomy memory oxidative stress |
| title | High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner |
| title_full | High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner |
| title_fullStr | High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner |
| title_full_unstemmed | High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner |
| title_short | High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner |
| title_sort | high fructose and high fat diet impair different types of memory through oxidative stress in a sex and hormone dependent manner |
| topic | metabolic syndrome ovariectomy orchiectomy memory oxidative stress |
| url | https://www.mdpi.com/2218-1989/12/4/341 |
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