Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination

Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination

Abstract Background Microglia are the primary phagocytes of the central nervous system and are responsible for removing damaged myelin following demyelination. Previous investigations exploring the consequences of myelin phagocytosis on microglial activation overlooked the biochemical modifications...

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Bibliographic Details
Main Authors: Miranda M. Standiford, Ethan M. Grund, Charles L. Howe
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Myelin
Citrullination
TNFα
Remyelination
Online Access:https://doi.org/10.1186/s12974-021-02360-3

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