A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response
Introduction We report a rare case of marked rectal stenosis due to Douglas' pouch metastasis of renal pelvic urothelial carcinoma successfully treated with enfortumab vedotin. Case presentation A 77‐year‐old female presented with difficulty in defecation and abdominal distension. She had recei...
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | IJU Case Reports |
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| Online Access: | https://doi.org/10.1002/iju5.12645 |
| _version_ | 1827762360267309056 |
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| author | Jun Akatsuka Go Kimura Akifumi Katsu Hiroya Hasegawa Hikaru Mikami Masato Yanagi Yuki Endo Hayato Takeda Yuka Toyama Yukihiro Kondo |
| author_facet | Jun Akatsuka Go Kimura Akifumi Katsu Hiroya Hasegawa Hikaru Mikami Masato Yanagi Yuki Endo Hayato Takeda Yuka Toyama Yukihiro Kondo |
| author_sort | Jun Akatsuka |
| collection | DOAJ |
| description | Introduction We report a rare case of marked rectal stenosis due to Douglas' pouch metastasis of renal pelvic urothelial carcinoma successfully treated with enfortumab vedotin. Case presentation A 77‐year‐old female presented with difficulty in defecation and abdominal distension. She had received two courses of cisplatin plus gemcitabine followed by four courses of maintenance avelumab for postoperative lymph node metastasis of renal pelvic urothelial carcinoma. KL‐6 levels were elevated, and a computed tomography scan revealed an irregularly shaped large mass occupying Douglas' pouch, with marked rectal stenosis. Metastatic urothelial carcinoma was pathologically diagnosed, and enfortumab vedotin was initiated after colostomy. After 12 courses of enfortumab vedotin, metastatic lesions showed marked shrinkage and KL‐6 levels decreased. Conclusion Enfortumab vedotin elicited a remarkable response in treating rectal stenosis due to metastasis of renal pelvic urothelial carcinoma in Douglas' pouch. Furthermore, serum KL‐6 levels were correlated with the severity of metastatic urothelial carcinoma. |
| first_indexed | 2024-03-11T10:28:31Z |
| format | Article |
| id | doaj.art-51d17c72a77345a29a4b65d034b78846 |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-03-11T10:28:31Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-51d17c72a77345a29a4b65d034b788462023-11-15T06:01:08ZengWileyIJU Case Reports2577-171X2023-11-016644945310.1002/iju5.12645A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor responseJun Akatsuka0Go Kimura1Akifumi Katsu2Hiroya Hasegawa3Hikaru Mikami4Masato Yanagi5Yuki Endo6Hayato Takeda7Yuka Toyama8Yukihiro Kondo9Department of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanDepartment of Urology Nippon Medical School Tokyo JapanIntroduction We report a rare case of marked rectal stenosis due to Douglas' pouch metastasis of renal pelvic urothelial carcinoma successfully treated with enfortumab vedotin. Case presentation A 77‐year‐old female presented with difficulty in defecation and abdominal distension. She had received two courses of cisplatin plus gemcitabine followed by four courses of maintenance avelumab for postoperative lymph node metastasis of renal pelvic urothelial carcinoma. KL‐6 levels were elevated, and a computed tomography scan revealed an irregularly shaped large mass occupying Douglas' pouch, with marked rectal stenosis. Metastatic urothelial carcinoma was pathologically diagnosed, and enfortumab vedotin was initiated after colostomy. After 12 courses of enfortumab vedotin, metastatic lesions showed marked shrinkage and KL‐6 levels decreased. Conclusion Enfortumab vedotin elicited a remarkable response in treating rectal stenosis due to metastasis of renal pelvic urothelial carcinoma in Douglas' pouch. Furthermore, serum KL‐6 levels were correlated with the severity of metastatic urothelial carcinoma.https://doi.org/10.1002/iju5.12645biomarkerKL‐6rectal stenosisrenal pelvic urothelial carcinoma |
| spellingShingle | Jun Akatsuka Go Kimura Akifumi Katsu Hiroya Hasegawa Hikaru Mikami Masato Yanagi Yuki Endo Hayato Takeda Yuka Toyama Yukihiro Kondo A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response IJU Case Reports biomarker KL‐6 rectal stenosis renal pelvic urothelial carcinoma |
| title | A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response |
| title_full | A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response |
| title_fullStr | A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response |
| title_full_unstemmed | A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response |
| title_short | A case of marked rectal stenosis due to Douglas’ pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL‐6 levels and tumor response |
| title_sort | case of marked rectal stenosis due to douglas pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin correlation between serum kl 6 levels and tumor response |
| topic | biomarker KL‐6 rectal stenosis renal pelvic urothelial carcinoma |
| url | https://doi.org/10.1002/iju5.12645 |
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