Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)
Abstract Background To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell count ratio, a marker of chronic inflammation, in virally suppressed people living with HIV-1 (PLWH) in Nouvelle Aquitaine, France. Methods A multi-centric, cross-sectio...
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BMC
2023-01-01
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Series: | BMC Infectious Diseases |
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Online Access: | https://doi.org/10.1186/s12879-022-07963-6 |
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author | Sophie Devos Fabrice Bonnet Mojgan Hessamfar Didier Neau Marc-Olivier Vareil Olivier Leleux Charles Cazanave Nicolas Rouanes Pierre Duffau Estibaliz Lazaro François Dabis Linda Wittkop Diana Barger ANRS CO3-AQUIVIH-NA-QuAliV |
author_facet | Sophie Devos Fabrice Bonnet Mojgan Hessamfar Didier Neau Marc-Olivier Vareil Olivier Leleux Charles Cazanave Nicolas Rouanes Pierre Duffau Estibaliz Lazaro François Dabis Linda Wittkop Diana Barger ANRS CO3-AQUIVIH-NA-QuAliV |
author_sort | Sophie Devos |
collection | DOAJ |
description | Abstract Background To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell count ratio, a marker of chronic inflammation, in virally suppressed people living with HIV-1 (PLWH) in Nouvelle Aquitaine, France. Methods A multi-centric, cross-sectional analysis was conducted in 2018–19 in the QuAliV study—ANRS CO3 AQUIVIH-NA cohort. Tobacco, alcohol, cannabis, and other drug use (poppers, cocaine, amphetamines, synthetic cathinones, GHB/GBL) were self-reported. CD4 and CD8 T cell counts and viral load measures, ± 2 years of self-report, and other characteristics were abstracted from medical records. Univariable and multivariable linear regression models, adjusted for age, sex, HIV risk group, time since HIV diagnosis, and other drug use were fit for each drug and most recent CD4/CD8 ratio. Results 660 PLWH, aged 54.7 ± 11.2, were included. 47.7% [315/660] had a CD4/CD8 ratio of < 1. Their mean CD4/CD8 ratio was 1.1 ± 0.6. 35% smoked; ~ 40% were considered to be hazardous drinkers or have alcohol use disorder; 19.9% used cannabis and 11.9% other drugs. Chemsex-associated drug users’ CD4/CD8 ratio was on average 0.226 (95% confidence interval [95% CI] − 0.383, − 0.070) lower than that of non-users in univariable analysis (p = 0.005) and 0.165 lower [95% CI − 0.343, 0.012] in multivariable analysis (p = 0.068). Conclusions Mean differences in CD4/CD8 ratio were not significantly different in tobacco, alcohol and cannabis users compared to non-users. However, Chemsex-associated drug users may represent a population at risk of chronic inflammation, the specific determinants of which merit further investigation. Trial registration number: NCT03296202. |
first_indexed | 2024-04-10T22:50:19Z |
format | Article |
id | doaj.art-51d31983fe394234a704cfad34ea59a3 |
institution | Directory Open Access Journal |
issn | 1471-2334 |
language | English |
last_indexed | 2024-04-10T22:50:19Z |
publishDate | 2023-01-01 |
publisher | BMC |
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series | BMC Infectious Diseases |
spelling | doaj.art-51d31983fe394234a704cfad34ea59a32023-01-15T12:05:20ZengBMCBMC Infectious Diseases1471-23342023-01-012311810.1186/s12879-022-07963-6Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)Sophie Devos0Fabrice Bonnet1Mojgan Hessamfar2Didier Neau3Marc-Olivier Vareil4Olivier Leleux5Charles Cazanave6Nicolas Rouanes7Pierre Duffau8Estibaliz Lazaro9François Dabis10Linda Wittkop11Diana Barger12ANRS CO3-AQUIVIH-NA-QuAliVUniv. Bordeaux, INSERM, BPH, U1219Univ. Bordeaux, INSERM, BPH, U1219Univ. Bordeaux, INSERM, BPH, U1219CHU de Bordeaux, Service des Maladies Infectieuses et Tropicales, INSERM, U1219Centre Hospitalier de la Côte Basque, Service de Maladies InfectieusesUniv. Bordeaux, INSERM, Institut Bergonié, BPH, U1219, CIC-P 1401CHU de Bordeaux, Service des Maladies Infectieuses et Tropicales, INSERM, U1219Centre Hospitalier de Périgueux, Service de Médecine PolyvalenteCHU de Bordeaux, Service de Médecine Interne et Maladies Infectieuses, INSERM, U1219CHU de Bordeaux, Service de Médecine InterneUniv. Bordeaux, INSERM, BPH, U1219Univ. Bordeaux, INSERM, BPH, U1219Univ. Bordeaux, INSERM, BPH, U1219Abstract Background To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell count ratio, a marker of chronic inflammation, in virally suppressed people living with HIV-1 (PLWH) in Nouvelle Aquitaine, France. Methods A multi-centric, cross-sectional analysis was conducted in 2018–19 in the QuAliV study—ANRS CO3 AQUIVIH-NA cohort. Tobacco, alcohol, cannabis, and other drug use (poppers, cocaine, amphetamines, synthetic cathinones, GHB/GBL) were self-reported. CD4 and CD8 T cell counts and viral load measures, ± 2 years of self-report, and other characteristics were abstracted from medical records. Univariable and multivariable linear regression models, adjusted for age, sex, HIV risk group, time since HIV diagnosis, and other drug use were fit for each drug and most recent CD4/CD8 ratio. Results 660 PLWH, aged 54.7 ± 11.2, were included. 47.7% [315/660] had a CD4/CD8 ratio of < 1. Their mean CD4/CD8 ratio was 1.1 ± 0.6. 35% smoked; ~ 40% were considered to be hazardous drinkers or have alcohol use disorder; 19.9% used cannabis and 11.9% other drugs. Chemsex-associated drug users’ CD4/CD8 ratio was on average 0.226 (95% confidence interval [95% CI] − 0.383, − 0.070) lower than that of non-users in univariable analysis (p = 0.005) and 0.165 lower [95% CI − 0.343, 0.012] in multivariable analysis (p = 0.068). Conclusions Mean differences in CD4/CD8 ratio were not significantly different in tobacco, alcohol and cannabis users compared to non-users. However, Chemsex-associated drug users may represent a population at risk of chronic inflammation, the specific determinants of which merit further investigation. Trial registration number: NCT03296202.https://doi.org/10.1186/s12879-022-07963-6CD4/CD8 ratioChronic inflammationChemsexDrug useHIV |
spellingShingle | Sophie Devos Fabrice Bonnet Mojgan Hessamfar Didier Neau Marc-Olivier Vareil Olivier Leleux Charles Cazanave Nicolas Rouanes Pierre Duffau Estibaliz Lazaro François Dabis Linda Wittkop Diana Barger ANRS CO3-AQUIVIH-NA-QuAliV Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) BMC Infectious Diseases CD4/CD8 ratio Chronic inflammation Chemsex Drug use HIV |
title | Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) |
title_full | Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) |
title_fullStr | Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) |
title_full_unstemmed | Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) |
title_short | Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV) |
title_sort | tobacco alcohol cannabis and illicit drug use and their association with cd4 cd8 cell count ratio in people with controlled hiv a cross sectional study anrs co3 aquivih na qualiv |
topic | CD4/CD8 ratio Chronic inflammation Chemsex Drug use HIV |
url | https://doi.org/10.1186/s12879-022-07963-6 |
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