Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
<p>Abstract</p> <p>Background</p> <p>Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be assoc...
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/3/297 |
| _version_ | 1818157850410614784 |
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| author | Cheng Ye Rachagani Satyanarayana Reecy James M |
| author_facet | Cheng Ye Rachagani Satyanarayana Reecy James M |
| author_sort | Cheng Ye |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle.</p> <p>Findings</p> <p>Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5).</p> <p>Conclusions</p> <p>Myostatin may regulates the expression of miRNAs such as <it>miR-133a</it>, <it>miR-133b</it>, <it>miR-1</it>, and <it>miR-206 </it>in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue.</p> |
| first_indexed | 2024-12-11T15:20:45Z |
| format | Article |
| id | doaj.art-51d3710debe04d2ba43bce0dfaf81d6b |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-11T15:20:45Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-51d3710debe04d2ba43bce0dfaf81d6b2022-12-22T01:00:22ZengBMCBMC Research Notes1756-05002010-11-013129710.1186/1756-0500-3-297Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscleCheng YeRachagani SatyanarayanaReecy James M<p>Abstract</p> <p>Background</p> <p>Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle.</p> <p>Findings</p> <p>Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5).</p> <p>Conclusions</p> <p>Myostatin may regulates the expression of miRNAs such as <it>miR-133a</it>, <it>miR-133b</it>, <it>miR-1</it>, and <it>miR-206 </it>in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue.</p>http://www.biomedcentral.com/1756-0500/3/297 |
| spellingShingle | Cheng Ye Rachagani Satyanarayana Reecy James M Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle BMC Research Notes |
| title | Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle |
| title_full | Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle |
| title_fullStr | Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle |
| title_full_unstemmed | Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle |
| title_short | Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle |
| title_sort | myostatin genotype regulates muscle specific mirna expression in mouse pectoralis muscle |
| url | http://www.biomedcentral.com/1756-0500/3/297 |
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